HIMIYAMA Tomoki

Research field (2)： Structural biochemistry , Molecular biochemistry

Research keywords (3)：タンパク質 , バイオプラスチック , バイオベース素材

Research theme for competitive and other funds (5)：

2024 - 2027 ペルオキシレドキシンを基盤とした光応答性タンパク質ケージの設計と構築
2020 - 2023 Supramolecular complex of peroxiredoxin
2020 - 2022 Structural and functional regulation of a ring-type protein quaternary structure
2018 - 2019 超好熱性古細菌由来ペルオキシレドキシンを基盤とする新規人工金属酵素の開発
2014 - 2016 生体分子・金属錯体と半導体ナノ粒子間の階層的電子伝達を介した複合型光触媒系構築

Papers (22)：

Yuqi Zhang, Yoshitaka Nakajima, Masae Kurobe, Tsutomu Nakamura, Tomoki Himiyama, Yoshiaki Nishiya. Structural and functional analysis of Bacillus sarcosine oxidase and its activity toward cyclic imino acids. FEBS Open Bio. 2025
Akiko Ueno, Fumiko Takida, Tomoki Kita, Takuro Ishii, Tomoki Himiyama, Takuya Mabuchi, Yasunori Okamoto. A cytokine-based designer enzyme with an abiological multinuclear metal center exhibits intrinsic and extrinsic catalysis. Nature Communications. 2025. 16. 1
Makoto Ihara, Noriko Tsuchida, Marina Sumida, Tomoki Himiyama, Takashi Kitayama, Norifumi Shirasaka, Yasuhisa Fukuta. Crystal Structure of the Native Chromoprotein from Pleurotus salmoneostramineus Provides Insights into the Pigmentation Mechanism. Journal of Agricultural and Food Chemistry. 2024
Yoshiyuki Kagawa, Koji Oohora, Tomoki Himiyama, Akihiro Suzuki, Takashi Hayashi. Redox Engineering of Myoglobin by Cofactor Substitution to Enhance Cyclopropanation Reactivity. Angewandte Chemie - International Edition. 2024
Tomoki Himiyama, Tasuku Hamaguchi, Koji Yonekura, Tsutomu Nakamura. Unnaturally Distorted Hexagonal Protein Ring Alternatingly Reorganized from Two Distinct Chemically Modified Proteins. Bioconjugate Chemistry. 2023

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MISC (8)：

米田菜織, 米田菜織, 氷見山幹基, 長澤壯柄, 長澤壯柄, 佐々本康平, 佐々本康平, 加塩健悟, 大嶋真紀, 倉田淳志, et al. Characterization of an N-acyl-D-amino acid amidohydrolase form Pyrococcus abyssi. 日本農芸化学会大会講演要旨集(Web). 2022. 2022
武田悠杜, 佐々本康平, 佐々本康平, 下澤勇弥, 下澤勇弥, 氷見山幹基, 森芳邦彦, 大本貴士, 上垣浩一, 西矢芳昭, et al. Functional analysis of catalytic reaction and substrate recognition of thermophilic acetylxylan esterase. 日本農芸化学会大会講演要旨集(Web). 2022. 2022
佐々本康平, 佐々本康平, 下澤勇弥, 下澤勇弥, 氷見山幹基, 森芳邦彦, 大本貴士, 上垣浩一, 上垣浩一, 西矢芳昭, et al. Structural and functional analysis of TTE0866 acetylxylan esterase from Caldanaerobacter subterraneus. 日本農芸化学会大会講演要旨集(Web). 2021. 2021
佐々本康平, 佐々本康平, 下澤勇弥, 下澤勇弥, 氷見山幹基, 森芳邦彦, 大本貴士, 上垣浩一, 西矢芳昭, 中村努. Caldanaerobacter由来アセチルキシランエステラーゼの構造決定と反応性評価. 日本蛋白質科学会年会プログラム・要旨集. 2021. 21st
加塩健悟, 加塩健悟, 佐々本康平, 佐々本康平, 氷見山幹基, 倉田淳志, 中村努, 上垣浩一. Characterization of D-amino acid deacetylase from Thermomicrobium roseum. 日本農芸化学会大会講演要旨集(Web). 2020. 2020

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Patents (2)：

還元反応用固体触媒
ペルオキシレドキシンに基づく人工ヘテロオリゴマータンパク質

Education (2)：

2011 - 2016 Osaka University Graduate School of Engineering Department of Applied Chemistry
2007 - 2011 Osaka University School of Engineering Division of Applied Science

Work history (7)：

2025/10 - 現在 The University of Osaka Visiting Associate Professor
2025/04 - 現在国立研究開発法人産業技術総合研究所モレキュラーバイオシステム研究部門主任研究員
2018/07 - 2025/09 Osaka University Visiting Researcher
2023/10 - 2025/03 National Institute of Advanced Industrial Science and Technology
2018/04 - 2023/09 National Institute of Advanced Industrial Science and Technology Biomedical Research Institute Researcher

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Awards (9)：

2025/07 - 産業技術総合研究所生命工学領域領域長賞パラミロンの研究開発
2025/03 - 産業技術支援フェア in KANSAI 2024 Interesting Panel賞パラミロンを出発原料としたものづくり
2023/07 - 一般社団法人日本蛋白質科学会若手奨励賞
2019/12 - 16th Conference of the Asian Crystallographic Association Best Poster Award
2015/09 - Japan Society of Coordination Chemistry Student Presentation Award

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