Research keywords (3)：
protein crystal
, Synchrotron radiation
, X-ray crystallography
Research theme for competitive and other funds (4)：
2023 - 2027 Real-time structural dynamics analysis in protein crystal under controlled environmental conditions (temperature and pH).
2023 - 2026 速度論および熱力学的手法を用いた"in crystallo" 酵素反応解析
2020 - 2023 非凍結結晶を用いた“in crystallo”酵素反応解析
2017 - 2021 In crystallo thermodynamic analysis of the cofactor conformational change of copper amine oxidase
Papers (85)：
Kenji Fukui, Tatsuya Yamamoto, Takeshi Murakawa, Seiki Baba, Takashi Kumasaka, Takato Yano. Catalytic mechanism of the zinc-dependent MutL endonuclease reaction. Life Science Alliance. 2023. 6. 10. e202302001-e202302001
Seiki BABA, Takeshi MURAKAWA. X-ray Crystallographic Analysis of Copper Amine Oxidase in Physiological Environments using Humid Air and Glue-coating(HAG)Method. Nihon Kessho Gakkaishi. 2022. 64. 4. 285-289
Maya Nakatani, Shun-ya Nakahara, Kenji Fukui, Momoka Urano, Yuki Fujii, Takeshi Murakawa, Seiki Baba, Takashi Kumasaka, Hiroki Okanishi, Yoshikatsu Kanai, et al. Crystal structure of a nucleotide-binding domain of fatty acid kinase FakA from Thermus thermophilus HB8. Journal of Structural Biology. 2022. 214. 4. 107904-107904
Tetsuya Masuda, Kyohei Okubo, Seiki Baba, Mamoru Suzuki, Fumito Tani, Masayuki Yamasaki, Bunzo Mikami. Structure of thaumatin under acidic conditions: Structural insight into the conformations in lysine residues responsible for maintaining the sweetness after heat-treatment. Food chemistry. 2022. 389. 132996-132996
Samuel L Rose, Seiki Baba, Hideo Okumura, Svetlana V Antonyuk, Daisuke Sasaki, Tobias M Hedison, Muralidharan Shanmugam, Derren J Heyes, Nigel S Scrutton, Takashi Kumasaka, et al. Single crystal spectroscopy and multiple structures from one crystal (MSOX) define catalysis in copper nitrite reductases. Proceedings of the National Academy of Sciences of the United States of America. 2022. 119. 30. e2205664119
出原 啓介, 福井 健二, 村川 武志, 馬場 清喜, 熊坂 崇, 内山 和久, 矢野 貴人. DNAミスマッチ修復系エンドヌクレアーゼであるMutLのATP結合部位におけるリンチ症候群関連の変異はMutLの構造を不安定化させる-A Lynch syndrome-associated mutation at a Bergerat ATP-binding fold destabilizes the structure of the DNA mismatch repair endonuclease MutL. 大阪医科薬科大学医学会雑誌 = Journal of the Medical Association of Osaka Medical and Pharmaceutical University. 2021. 80. 1・2. 85-91
