Rchr
J-GLOBAL ID：201801018880189829   Update date: Mar. 28, 2024

Kanekura Kohsuke

カネクラ コウスケ | Kanekura Kohsuke
Affiliation and department：
Tokyo Medical University Department of pharmacology

About Tokyo Medical University Department of pharmacology


Job title： Professor
Homepage URL  (1)： http://www.tokyo-med.ac.jp/pharmacol/kanekura.html
Research field  (2)： Biophysics ,  Neuropathology
Research keywords  (5)： liquid liquid phase separation ,  multi-omics analysis ,  biosensor ,  Endoplasmic reticulum stress response ,  Amyotrophic lateral sclerosis
Research theme for competitive and other funds  (23)：
  • 2021 - 2025 Knowledge-driven Nanodrug design through understanding of a role of Phase-separated condensate in chemotherapy using Single-Cell endoscopy
  • 2020 - 2025 全能性獲得へのロードマップ:幹細胞のミトコンドリア・ゲノム安定性機構の解明
  • 2021 - 2024 インドシアニングリーンを用いた脳脊髄腫瘍の術中蛍光診断の確立と治療技術の開発
  • 2023 - TDP43の液液相分離制御技術の開発と液液相分離による神経変性機構の解明
  • 2020 - 2023 Understanding of signal transduction via peptides at the interface of cells and nanomaterials
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Papers (56)：
  • Hajime Iwasaki, Hirotsugu Suwanai, Fumiyoshi Yakou, Hiroyuki Sakai, Keitaro Ishii, Natsuko Hara, Ashley M. Buckle, Kohsuke Kanekura, Tamami Miyagi, Satoshi Narumi, et al. Disulfide bonds of thyroid peroxidase are critical elements for subcellular localization, proteasome-dependent degradation, and enzyme activity. Thyroid®. 2024
  • Tamami Miyagi, Koji Ueda, Masahiro Sugimoto, Takuya Yagi, Daisuke Ito, Rio Yamazaki, Satoshi Narumi, Yuhei Hayamizu, Hiroshi Uji-i, Masahiko Kuroda, et al. Differential toxicity and localization of arginine-rich C9ORF72 dipeptide repeat proteins depend on de-clustering of positive charges. iScience. 2023. 26. 6. 106957-106957
  • Kohsuke Kanekura, Yoshiaki Yamanaka, Tamami Miyagi, Masahiko Kuroda. Chemically oligomerizable TDP-43: a novel chemogenetic tool for studying the pathophysiology of amyotrophic lateral sclerosis. Neural regeneration research. 2022. 17. 11. 2434-2436
  • Kohsuke Kanekura, Masahiko Kuroda. How can we interpret the relationship between liquid-liquid phase separation and amyotrophic lateral sclerosis?. Laboratory investigation; a journal of technical methods and pathology. 2022. 102. 9. 912-918
  • Tamami Miyagi, Rio Yamazaki, Koji Ueda, Satoshi Narumi, Yuhei Hayamizu, Hiroshi Uji-I, Masahiko Kuroda, Kohsuke Kanekura. The Patterning and Proportion of Charged Residues in the Arginine-Rich Mixed-Charge Domain Determine the Membrane-Less Organelle Targeted by the Protein. International journal of molecular sciences. 2022. 23. 14
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MISC (31)：
  • 金蔵 孝介, 宮城 碧水, 黒田 雅彦. C9orf72由来ポリ(PR)の構造-機能相関(Structure-function relationships in C9orf72-derived poly(PR)). 老年精神医学雑誌. 2022. 33. 増刊II. 254-254
  • 金蔵 孝介, 宮城 碧水, 黒田 雅彦. C9orf72由来ポリ(PR)の構造-機能相関(Structure-function relationships in C9orf72-derived poly(PR)). Dementia Japan. 2022. 36. 4. 756-756
  • 金蔵 孝介, 山中 喜晃, 黒田 雅彦. 哺乳類細胞において筋萎縮性側索硬化症の病理を模倣する化学的にオリゴマー化可能なTAR DNA結合タンパク質-43の作製(Establishment of chemically oligomerizable TAR DNA-binding protein-43 which mimics amyotrophic lateral sclerosis pathology in mammalian cells). 東京医科大学雑誌. 2022. 80. 4. 367-367
  • 梅津 知宏, 柏木 怜, 村上 善基, 金蔵 孝介, 大野 慎一郎, 黒田 雅彦. 正常細胞および腫瘍細胞のCell-free DNAの産生メカニズムの解明とLiquid biopsyへの応用. 日本病理学会会誌. 2022. 111. 1. 319-319
  • 稲垣 夏子, 桐林 和代, 梅津 知宏, 武内 進, 備後 真登, 助田 葵, 金蔵 孝介, 長尾 俊孝, 沼部 博直, 林 由起子, et al. 東京医科大学病院におけるがんゲノム医療の現状と取り組み. 東京医科大学雑誌. 2021. 79. 2. 141-151
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Patents (2)：
Books (7)：
  • 東京医科大学雑誌
    2016
  • Science Signaling 2016 Issueシグナリングに載った日本人研究者
    2016
  • クリニカルニューロサイエンス
    2014
  • 脳21
    2013
  • Endoplasmic Reticulum Stress in Health and Disease;
    Springer 2012
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Lectures and oral presentations  (13)：
  • アミノ酸の性質から紐解くALS原因ジペプチドリピートの相分離と毒性機構
    (日本アミノ酸学会第16回学術集会 2022)
  • Alternating Arg distribution controls phase separation and toxicity of poly(PR)
    (2022)
  • Order controls disordered droplets: structure-function relationships in C9ORF72-derived poly(PR).
    (2nd International research conference on neurodegenerative diseases (IRCND 2022). 2022)
  • Alternating Arg distribution controls phase separation and toxicity of poly(PR)
    (2021)
  • Devices for unmet medical needs
    (The 80th JSAP Autumn Meeting 2019 2019)
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Education (2)：
  • 2002 - 2005 KEIO University Ph.D course in Medicine
  • 1996 - 2002 KEIO University School of Medicine
Professional career (1)：
  • 博士(医学) (慶應義塾大学)
Work history (10)：
  • 2023/04 - 現在 Tokyo Medical University Department of pharmacology
  • 2022/01 - 2023/03 Tokyo Medical University
  • 2015/06 - 2021/12 Tokyo Medical University Department of Molecular Pathology Assistant Professor
  • 2012/09 - 2015/05 Washington University St. Louis Senior Scientist
  • 2010/03 - 2012/08 マサチューセッツ州立大学 医学部 Postdoctoral fellow
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Awards (1)：
  • 2016 - Sasa Memorial Award IRE1 prevents endoplasmic reticulum membrane permeabilization and cell death during pathological conditions.
Association Membership(s) (4)：
日本薬理学会 ,  Society for neuroscience ,  JAPAN SOCIETY FOR DEMENTIA RESEARCH ,  THE JAPANESE BIOCHEMICAL SOCIETY
※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

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