Moriguchi Shigeki

モリグチシゲキ | Moriguchi Shigeki

Affiliation and department：
Job title： Associate Professor
Homepage URL (1)： http://www.pharm.tohoku.ac.jp/research_center/moriguchi_lab/

Research field (1)： Neuroscience - general

Research keywords (1)： Calcium signal, Cognitive/mental disorder, Dementia

Research theme for competitive and other funds (16)：

2004 - 現在カルシウム恒常性破綻による認知・精神機能障害の病態機序解明
2001 - 現在カルシウムシグナル賦活化によるアルツハイマー病創薬研究
2021 - 2024 KATPチャネルを標的としたアルツハイマー病周辺症状の病態発症機序の解明
2018 - 2021 Mechanisms of both cognitive deficits and behavioral and psychological symptoms of Alzheimer's disease in KATP channel mutant mice
2015 - 2018 Drug development of novel Kir6.2 channel inhibitor target for Alzheimer'ddisease

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Papers (83)：

Ryo Inagaki, Tohru Yamakuni, Takashi Saito, Takaomi C Saido, Shigeki Moriguchi. Preventive effect of propolis on cognitive decline in Alzheimer’s disease model mice. Neurobiology of Aging. 2024. 139. 20-29
Shigeki Moriguchi, Ryo Inagaki, Takashi Saito, Takaomi C. Saido, Kohji Fukunaga. Propolis promotes memantine-dependent rescue of cognitive deficits in APP-KI mice. Mol Neurobiol. 2022. 59. 4630-4646
Shigeki Moriguchi, Ryo Inagaki, Kohji Fukunaga. Memantine improves cognitive deficits via KATP channel inhibition in olfactory bulbectomized mice. Mol Cell Neurosci. 2021. 117. 103680
Osamu Nakagawasai, Lin Jia-Rong, Takayo Odaira, Kohei Takahashi, Wataru Nemoto, Shigeki Moriguchi, Yasushi Yabuki, Yu Kobayakawa, Kohji Fukunaga, Masahisa Nakada, et al. Scabronine G methyl ester improves memory-related behavior and enhances hippocampal cell proliferation and long-term potentiation via the BDNF-CREB pathway in olfactory bulbectomized mice. Front Pharmacol. 2020. 11. 583291-583291
Shigeki Moriguchi, Ryo Inagaki, Lusha Yi, Mikako Shibata, Hiroyuki Sakagami, Kohji Fukunaga. Nicotine rescues depressive-like behaviors via α7-type nicotinic acetylcholine receptor activation in CaMKIV null mice. Mol Neurobiol. 2020. 57. 12. 4929-4940

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Education (1)：

Professional career (1)：

Work history (8)：

2019/11 - 現在 Research Center for Pharmaceutical Development, Graduate School of Pharmaceutical Sciences, Tohoku University Associate Professor
2010/04 - 2019/10 Department of pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University Senior Assistant Professor
2011/04 - 2018/03 Miyagi Gakuin Women's University Lecturer
2009/09 - 2014/08 Department of Molecular Pharmacology and Biological Chemistry, Northwestern University, Chicago, U.S.A. Associate Professor
2007/04 - 2010/03 Department of pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University Assistant Professor

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Awards (13)：

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Association Membership(s) (5)：

日本神経精神薬理学会 , 日本薬学会 , 日本神経化学会 , 日本薬理学会 , 北米神経科学学会

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