Taichi Ohshiro

オオシロタイチ | Taichi Ohshiro

Affiliation and department：
Homepage URL (1)： https://www.kitasato-u.ac.jp/pharm/research/laboratory/laboratory-detail/?lab_pk=1669807811

Research field (2)： Environmental and pharmaceutical development resources , Pharmaceuticals - chemistry and drug development

Research keywords (2)：脂質代謝 , 天然物化学

Research theme for competitive and other funds (4)：

2018 - 2023 Collection and utilization of bioresources and natural products from Indonesia
2018 - 2021 中性脂質蓄積制御からの脂肪肝/脂肪肝炎の予防治療薬の開拓
2016 - 2018 微生物資源を用いた中性脂質生成制御からの創薬へのアプローチ
2006 - 2006 微生物由来マクロファージ泡沫化阻害剤beauveriolideに関する研究

Papers (67)：

Satoru Shigeno, Miyu Kadowaki, Kenichiro Nagai, Kanji Hosoda, Takeshi Terahara, Tomoyasu Nishimura, Naoki Hasegawa, Hiroshi Tomoda, Taichi Ohshiro. New polycyclic tetramate macrolactams with antimycobacterial activity produced by marine-derived Streptomyces sp. KKMA-0239. The Journal of Antibiotics. 2024
Kanji Hosoda, Nobuhiro Koyama, Satoru Shigeno, Tomoyasu Nishimura, Naoki Hasegawa, Akihiko Kanamoto, Taichi Ohshiro, Hiroshi Tomoda. Mavintramycin A is a promising antibiotic for treating Mycobacterium avium complex infectious disease. Antimicrobial Agents and Chemotherapy. 2024
Kenichiro Nagai, Keisuke Kobayashi, Ryosuke Miyake, Yukino Sato, Reiko Seki, Takashi Fukuda, Akiho Yagi, Ryuji Uchida, Taichi Ohshiro, Hiroshi Tomoda. Synthesis and biological evaluation of nectriatide derivatives, potentiators of amphotericin B activity. The Journal of antibiotics. 2024
Moeka Uemura, Keisuke Kobayashi, Noriko Sato, Kenichiro Nagai, Reiko Seki, Michiya Kamio, Takashi Fukuda, Taishi Tsubouchi, Hiroshi Tomoda, Taichi Ohshiro, et al. Haneummycin, a new 22-membered macrolide lactam antibiotic, produced by marine-derived Streptomyces sp. KM77-8. The Journal of Antibiotics. 2023
Kotaro Tanaka, Shou Suzuki, Daiki Lee, Shiho Arima, Satoshi Ohte, Taichi Ohshiro, Ryuji Uchida, Hiroshi Tomoda, Tohru Nagamitsu. Total synthesis of tanzawaic acid A. Tetrahedron. 2023. 133556-133556

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MISC (4)：

Tumenbayar Bayasgalan, Shuichi Nagashima, Hiroaki Yagyu, Fumiko Tazoe, Ken Ohashi, Manabu Takahashi, Taichi Ohshiro, Motohiro Sekiya, Jun-ichi Osuga, Shun Ishibashi. Macrophage-Specific Disruption of HMG-CoA Reductase Inhibited the Development of Atherosclerosis. CIRCULATION. 2011. 124. 21
Taichi Ohshiro, Daisuke Matsuda, Kent Sakai, Chiara Degirolamo, Hiroaki Yagyu, Lawrence L. Rudel, Satoshi Omura, Shun Ishibashi, Hiroshi Tomoda. Pyripyropene A, a Selective Inhibitor of Acyl-CoA:cholesterol Acyltransferase 2, Attenuates Hypercholesterolemia and Atherosclerosis in Murine Models of Hyperlipidemia. CIRCULATION. 2010. 122. 21
松田大介, 大城太一, 供田洋. スタチンを超える薬物療法の可能性 (特集脂質異常症--基本を踏まえた実践) -- (残された課題). 内科. 2009. 103. 1. 137-140
Application to combinatorial synthesis of fungal beauveriolides for drug development. Bio industry. 2007. 24. 7. 39-47

Patents (9)：

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Books (3)：

Lectures and oral presentations (32)：

プロダクトイオンを指標としたSOAT2選択的阻害剤の探索
(日本薬学会第 143 年会 2023)
なぜ nectriatide は抗真菌剤 amphotericin B の活性を増強するのか?
(日本薬学会第 143 年会 2023)
SOAT2選択的阻害剤PRD125はPCSK9量も低下させる!
(日本薬学会第 143 年会 2023)
微生物由来抗結核剤 calpinactam の標的分子の解析
(日本薬学会第 143 年会 2023)
New Tripeptide Derivatives Asterripeptides A-C from Vietnamese Mangrove-Derived Fungus Aspergillus terreus LM.5.2
(日本薬学会第 143 年会 2023)

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Education (3)：

2004 - 2007 Kitasato University Graduate School of Infectioncontrol Sciences
2002 - 2004 Kitasato University Graduate School of Infectioncontrol Sciences
1998 - 2002 Kitasato University School of Pharmaceutical Sciences Faculty of Pharmaceutical Sciences

Work history (10)：

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Awards (1)：

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