Art
J-GLOBAL ID：201802211829766529   Reference number：18A1601542

Phase II trial of biweekly cetuximab and irinotecan as third-line therapy for pretreated KRAS exon 2 wild-type colorectal cancer

前治療を受けたKRASエクソン2野生型結腸直腸癌 に対する3次治療としての隔週投与のセツキシマブとイリノテカンの第II相試験
Author (13)：
Osumi Hiroki

About Osumi Hiroki

(Department of Gastroenterology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan)

About Department of Gastroenterology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan

, 
Shinozaki Eiji

About Shinozaki Eiji

(Department of Gastroenterology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan)

About Department of Gastroenterology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan

, 
Mashima Tetsuo

About Mashima Tetsuo

(Division of Molecular Biotherapy, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo, Japan)

About Division of Molecular Biotherapy, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo, Japan

, 
Wakatsuki Takeru

About Wakatsuki Takeru

(Department of Gastroenterology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan)

About Department of Gastroenterology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan

, 
Suenaga Mitsukuni

About Suenaga Mitsukuni

(Department of Gastroenterology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan)

About Department of Gastroenterology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan

, 
Ichimura Takashi

About Ichimura Takashi

(Department of Gastroenterology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan)

About Department of Gastroenterology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan

, 
Ogura Mariko

About Ogura Mariko

(Department of Gastroenterology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan)

About Department of Gastroenterology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan

, 
Ota Yumiko

About Ota Yumiko

(Department of Gastroenterology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan)

About Department of Gastroenterology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan

, 
Nakayama Izuma

About Nakayama Izuma

(Department of Gastroenterology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan)

About Department of Gastroenterology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan

, 
Takahari Daisuke

About Takahari Daisuke

(Department of Gastroenterology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan)

About Department of Gastroenterology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan

, 
Chin Keisho

About Chin Keisho

(Department of Gastroenterology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan)

About Department of Gastroenterology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan

, 
Miki Yoshio

About Miki Yoshio

(Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan)

About Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan

, 
Yamaguchi Kensei

About Yamaguchi Kensei

(Department of Gastroenterology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan)

About Department of Gastroenterology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan


Material：
Cancer Science (Web)  (Cancer Sci (Web))

About Cancer Science (Web)


Volume： 109  Issue： 8  Page： 2567-2575  Publication year： 2018 
JST Material Number： U0505A  ISSN： 1349-7006  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)
Thesaurus term：
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phase 2 study

About phase 2 study

,...
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All keywords is available on JDreamIII(charged).
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genetic variation

About genetic variation

,...
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Author keywords (5)：
biweekly cetuximab

About biweekly cetuximab

, 
BRAF mutation

About BRAF mutation

, 
colorectal cancer

About colorectal cancer

, 
early tumor shrinkage

About early tumor shrinkage

, 
RAS mutation

About RAS mutation

JST classification (4)：
JST classification
Category name(code) classified by JST.
Clinical application of antitumor(=antineoplastic)drugs 
(GW16020L)

About Clinical application of antitumor(=antineoplastic)drugs

,  Drug therapy(=pharmacotherapy)for tumors 
(GE03032C)

About Drug therapy(=pharmacotherapy)for tumors

,  Tumors(=neoplasms)of digestive system 
(GH04000D)

About Tumors(=neoplasms)of digestive system

,  Molecular genetics in general 
(EC02010J)

About Molecular genetics in general

Substance index (1)：
Substance index
Chemical Substance indexed to the Article.
Irinotecan

About Irinotecan

Terms in the title (9)：
Terms in the title
Keywords automatically extracted from the title.
治療

About 治療

, 
KRAS

About KRAS

, 
エクソン

About エクソン

, 
野生型

About 野生型

, 
結腸直腸癌

About 結腸直腸癌

, 
隔週投与

About 隔週投与

, 
セツキシマブ

About セツキシマブ

, 
イリノテカン

About イリノテカン

, 
第II相試験

About 第II相試験


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