Art

J-GLOBAL ID：201802211877776204   Reference number：18A1010898

Development of a Caco-2 Cell Line Carrying the Human Intestine-Type CES Expression Profile as a Promising Tool for Ester-Containing Drug Permeability Studies

エステル含有薬物透過性研究のための有望なツールとしてのヒト腸型CES発現プロファイルを持つCaco-2細胞株の開発

Author (9)： Ishizaki Yuma (Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University) ,  Furihata Tomomi (Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University) ,  Furihata Tomomi (Department of Pharmacology, Graduate School of Medicine, Chiba University) ,  Oyama Yusuke (Department of Metabolism-Based Drug Design and Delivery, Graduate School of Pharmaceutical Science, Kumamoto University) ,  Ohura Kayoko (Department of Metabolism-Based Drug Design and Delivery, Graduate School of Pharmaceutical Science, Kumamoto University) ,  Imai Teruko (Department of Metabolism-Based Drug Design and Delivery, Graduate School of Pharmaceutical Science, Kumamoto University) ,  Hosokawa Masakiyo (Laboratory of Drug Metabolism and Biopharmaceutics, Faculty of Pharmaceutical Sciences, Chiba Institute of Science) ,  Akita Hidetaka (Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University) ,  Chiba Kan (Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University)
Material： Biological and Pharmaceutical Bulletin (Web)
Volume： 41  Issue： 5  Page： 697-706(J-STAGE)  Publication year： 2018 
JST Material Number： U1402A  ISSN： 1347-5215  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *Caco2 cell ,...
Semi thesaurus term： *Carboxylesterase 2 ,...

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Author keywords (10)： carboxylesterase ,  Caco-2 cell ,  prodrug ,  drug permeability ,  small intestine ,  carboxylesterase ,  Caco-2 cell ,  prodrug ,  drug permeability ,  small intestine

JST classification (3)： Laboratry organisms  (EA03070Y) ,  Basic biopharmacy  (GY01021U) ,  Basic medicine on digestive system  (GH01020E)

Reference (34)：

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• 3) Laizure SC, Herring V, Hu Z, Witbrodt K, Parker RB. The role of human carboxylesterases in drug metabolism: have we overlooked their importance? Pharmacotherapy, 33, 210-222 (2013).
• 4) Humerickhouse R, Lohrbach K, Li L, Bosron WF, Dolan ME. Characterization of CPT-11 hydrolysis by human liver carboxylesterase isoforms hCE-1 and hCE-2. Cancer Res., 60, 1189-1192 (2000).
• 5) Tang M, Mukundan M, Yang J, Charpentier N, LeCluyse EL, Black C, Yang D, Shi D, Yan B. Antiplatelet agents aspirin and clopidogrel are hydrolyzed by distinct carboxylesterases, and clopidogrel is transesterificated in the presence of ethyl alcohol. J. Pharmacol. Exp. Ther., 319, 1467-1476 (2006).

Terms in the title (11)： エステル ,  薬物 ,  透過性 ,  研究 ,  ツール ,  ヒト ,  腸 ,  発現プロファイル ,  Caco-2 ,  細胞株 ,  開発