Art

J-GLOBAL ID：201802213431237459   Reference number：18A1010925

Production and rearing of germ-free X-SCID pigs

無菌X-SCIDブタの作製と飼育

Author (17)： Hara Hiromasa (Division of Regenerative Medicine, Center for Molecular Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan) ,  Shibata Hiroaki (Division of Regenerative Medicine, Center for Molecular Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan) ,  Shibata Hiroaki (Center for Development of Advanced Medical Technology, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan) ,  Nakano Kazuaki (Department of Life Sciences, School of Agriculture, Meiji University, 1-1-1 Higashi-Mita, Tama, Kawasaki, Kanagawa 214-8571, Japan) ,  Abe Tomoyuki (Division of Regenerative Medicine, Center for Molecular Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan) ,  Abe Tomoyuki (Center for Development of Advanced Medical Technology, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan) ,  Uosaki Hideki (Division of Regenerative Medicine, Center for Molecular Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan) ,  Uosaki Hideki (Center for Development of Advanced Medical Technology, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan) ,  Ohnuki Takahiro (Center for Development of Advanced Medical Technology, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan) ,  Hishikawa Shuji (Center for Development of Advanced Medical Technology, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan) ,  Kunita Satoshi (Center for Development of Advanced Medical Technology, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan) ,  Watanabe Masahito (Meiji University International Institute for Bio-Resource Research, 1-1-1 Higashi-Mita, Tama, Kawasaki, Kanagawa 214-8571, Japan) ,  Nureki Osamu (Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 2-11-16 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan) ,  Nagashima Hiroshi (Department of Life Sciences, School of Agriculture, Meiji University, 1-1-1 Higashi-Mita, Tama, Kawasaki, Kanagawa 214-8571, Japan) ,  Nagashima Hiroshi (Meiji University International Institute for Bio-Resource Research, 1-1-1 Higashi-Mita, Tama, Kawasaki, Kanagawa 214-8571, Japan) ,  Hanazono Yutaka (Division of Regenerative Medicine, Center for Molecular Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan) ,  Hanazono Yutaka (Center for Development of Advanced Medical Technology, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan)
Material： Experimental Animals  (実験動物ニュース)
Volume： 67  Issue： 2  Page： 139-146(J-STAGE)  Publication year： 2018 
JST Material Number： Z0755A  ISSN： 1341-1357  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *swine ,...
Semi thesaurus term： IL2RG遺伝子 ,...

Register(free) or Log In to access     To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=18A1010925&from=J-GLOBAL&jstjournalNo=Z0755A") }}

Author keywords (4)： germ-free pig ,  gnotobiote ,  interleukin-2 receptor gamma chain gene (IL2RG) knock-out ,  X-linked severe combined immunodeficiency (X-SCID)

JST classification (3)： Immunologic diseases,allergic diseases in general.  (GD04010C) ,  Laboratry organisms  (EA03070Y) ,  Research methods in genetics  (EC01020N)

Reference (24)：

• 1. Buckley R.H. 2004. Molecular defects in human severe combined immunodeficiency and approaches to immune reconstitution. Annu. Rev. Immunol. 22: 625-655.
• 2. Cao X., Shores E.W., Hu-Li J., Anver M.R., Kelsall B.L., Russell S.M., Drago J., Noguchi M., Grinberg A., Bloom E.T., Paul W.E., Katz S.I., Love P.E., and Leonard W.J. 1995. Defective lymphoid development in mice lacking expression of the common cytokine receptor gamma chain. Immunity 2: 223-238.
• 3. Charbonneau M.R., O’Donnell D., Blanton L.V., Totten S.M., Davis J.C., Barratt M.J., Cheng J., Guruge J., Talcott M., Bain J.R., Muehlbauer M.J., Ilkayeva O., Wu C., Struckmeyer T., Barile D., Mangani C., Jorgensen J., Fan Y.M., Maleta K., Dewey K.G., Ashorn P., Newgard C.B., Lebrilla C., Mills D.A., and Gordon J.I. 2016. Sialylated milk oligosaccharides promote microbiota-dependent growth in models of infant undernutrition. Cell 164: 859-871.
• 4. Fujishiro S.H., Nakano K., Mizukami Y., Azami T., Arai Y., Matsunari H., Ishino R., Nishimura T., Watanabe M., Abe T., Furukawa Y., Umeyama K., Yamanaka S., Ema M., Nagashima H., and Hanazono Y. 2013. Generation of naive-like porcine-induced pluripotent stem cells capable of contributing to embryonic and fetal development. Stem Cells Dev. 22: 473-482.
• 5. Giovanella B.C., Stehlin J.S., Wall M.E., Wani M.C., Nicholas A.W., Liu L.F., Silber R., and Potmesil M. 1989. DNA topoisomerase I--targeted chemotherapy of human colon cancer in xenografts. Science 246: 1046-1048.

Terms in the title (5)： 無菌 ,  SCID ,  ブタ ,  作製 ,  飼育