Art

J-GLOBAL ID：201802214644034354   Reference number：18A1758327

Sensitive and Comprehensive LC-MS/MS Analyses of Chiral Pharmaceuticals and Their Hepatic Metabolites Using Ovomucoid Column

オボムコイドカラムを用いたキラル医薬品とそれらの肝代謝産物の高感度で包括的なLC-MS/MS分析

Author (11)： TODOROKI Kenichiro (Laboratory of Analytical and Bio-Analytical Chemistry, School of Pharmaceutical Sciences, University of Shizuoka) ,  KUDOH Yuto (Laboratory of Analytical and Bio-Analytical Chemistry, School of Pharmaceutical Sciences, University of Shizuoka) ,  NAKAMURA Misuzu (Laboratory of Analytical and Bio-Analytical Chemistry, School of Pharmaceutical Sciences, University of Shizuoka) ,  SHIMIZU Yuki (Laboratory of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka) ,  SASAKI Takamitsu (Laboratory of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka) ,  OTSUKI Hideyuki (Shinwa Chemical Industries Ltd.) ,  WADA Keisuke (Shinwa Chemical Industries Ltd.) ,  MIN Jun Zhe (Key Laboratory for Natural Resource of Changbai Mountain & Functional Molecules, Ministry of Education, College of Pharmacy, Yanbian University) ,  MIZUNO Hajime (Laboratory of Analytical and Bio-Analytical Chemistry, School of Pharmaceutical Sciences, University of Shizuoka) ,  YOSHINARI Kouichi (Laboratory of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka) ,  TOYO'OKA Toshimasa (Laboratory of Analytical and Bio-Analytical Chemistry, School of Pharmaceutical Sciences, University of Shizuoka)
Material： Analytical Sciences  (Anal Sci)
Volume： 34  Issue： 9  Page： 1011-1015(J-STAGE)  Publication year： 2018 
JST Material Number： G0673B  ISSN： 0910-6340  CODEN： ANSCEN  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *ovomucoid ,...
Semi thesaurus term： *LC/MS/MS ,...

Register(free) or Log In to access     To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=18A1758327&from=J-GLOBAL&jstjournalNo=G0673B") }}

Author keywords (5)： Chiral pharmaceuticals ,  LC-MS/MS analysis ,  ovomucoid column ,  hepatic metabolites ,  CYP

JST classification (4)： Physical analysis of organic compounds  (CC03034A) ,  Basic biopharmacy  (GY01021U) ,  Analysis of drugs  (GV01040Q) ,  Chromatography and electrophoretic analysis of organic compounds  (CC04034H)

Substance index (12)： (+-)-Ibuprofen ,  (+-)-Chlorpheniramine ,  (+-)-Ketoprofen ,  (+-)-Benzhexol ,  (+-)-Naproxen ,  (+-)-Pindolol ,  (+-)-Propafenone ,  (+-)-Propranolol ,  (+-)-Verapamil ,  Formic acid ammonium ,  Loxoprofen ,  Warfarin potassium

Reference (30)：

• 1. A. R. Ribeiro, A. S. Maia, Q. B. Cass, and M. E. Tiritan, J. Chromatogr. B, 2014, 968, 8.
• 2. L. S. Kaminsky and Z.-Y. Zhang, Pharmacol. Ther., 1997, 73, 67.
• 3. A. N. Shaik, R. Grater, M. Lulla, D. A. Williams, L. L. Gan, T. Bohnert, and B. W. LeDuc, J. Chromatogr. B, 2016, 1008, 164.
• 4. M. Lämmerhofer, J. Chromatogr. A, 2010, 1217, 814.
• 5. M. Tang, J. Zhang, S. Zhuang, and W. Liu, Trends Anal. Chem., 2012, 39, 180.

Terms in the title (6)： キラル ,  医薬品 ,  代謝産物 ,  高感度 ,  LC-MS ,  MS分析