Art

J-GLOBAL ID：201802215128702750   Reference number：18A0694994

Degranulation inhibitors from the arils of Myristica fragrans in antigen-stimulated rat basophilic leukemia cells

抗原刺激ラット好塩基球性白血病細胞におけるMyristica fragransの種皮からの脱顆粒阻害剤

Author (7)： MORIKAWA Toshio (Kindai Univ., Osaka, JPN) ,  HACHIMAN Ikuko (Kindai Univ., Osaka, JPN) ,  NINOMIYA Kiyofumi (Kindai Univ., Osaka, JPN) ,  HATA Hiroki (Kyoto Pharmaceutical Univ., Kyoto, JPN) ,  SUGAWARA Kaoru (Kyoto Pharmaceutical Univ., Kyoto, JPN) ,  MURAOKA Osamu (Kindai Univ., Osaka, JPN) ,  MATSUDA Hisashi (Kyoto Pharmaceutical Univ., Kyoto, JPN)
Material： Journal of Natural Medicines  (J Nat Med)
Volume： 72  Issue： 2  Page： 464-473  Publication year： 2018 
JST Material Number： L5856A  ISSN： 1340-3443  Document type： Article
Article type： 原著論文  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Thesaurus term： *Myristica fragrans ,...
Semi thesaurus term： EI-MS(analysis) ,...

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JST classification (2)： Plant biochemistry  (EH01050J) ,  Basic research of enzyme preparations and enzyme inhibitor preparations  (GW21010W)

Substance index (29)： Dehydrodiisoeugenol ,  (-)-erythro-(7R,8S)-Δ^8′-7-Hydroxy-3,4,3′,5′-tetramethoxy-8-O-4′-neolignan ,  (-)-erythro-(7R,8S)-Δ^8′-7-Acetoxy-3,4-methylenedioxy-3′,5′-dimethoxy-8-O-4′-neolignan ,  Myrislignan ,  Rhaphidecursinol B ,  (1S,2R)-1-(1,3-Benzodioxol-5-yl)-2-(2,6-dimethoxy-4-allylphenoxy)-1-propanol ,  (+)-erythro-(7S,8R)-Δ^8′-4,7-Dihydroxy-3,3′,5′-trimethoxy-8-O-4′-neolignan ,  2,3-Dihydro-2α-guaiacyl-3β-methyl-7-methoxybenzofuran-5-carbaldehyde ,  Virolongin B ,  (-)-(8R)-Δ^8′-3,4-Methylenedioxy-3′,5′-dimethoxy-8-O-4′-neolignan ,  (-)-(8R)-Δ^8′-4-Hydroxy-3,3′,5′-trimethoxy-8-O-4′-neolignan ,  (-)-Miliusfragranol B ,  4-Allyl-2,6-dimethoxyphenol ,  Austrobailignan 5 ,  Anthriscinol ,  Nectandrin B ,  Maceneolignan A ,  Maceneolignan D ,  Maceneolignan F ,  Maceneolignan H ,  Maceneolignan I ,  Maceneolignan J ,  Maceneolignan K ,  Malabaricone C ,  Myristicin ,  Myrislignanometin E ,  Myrifralignan C ,  Licarin B ,  Verrucosin B

Reference (31)：

• Paul S, Hwang JK, Kim HY, Jeon WK, Chung C, Han J-S (2013) Multiple biological properties of macelignan and its pharmacological implications. Arch Pharm Res 36:264-272
• Nagja T, Vimal K, Sanjeev A (2016) Myristica fragrans: a comprehensive review. Int J Pharm Pharm Sci 8:27-30
• Acuña UM, Carcache PJB, Matthew S, de Blanco EJC (2016) New acyclic bis phenylpropanoid and neolignans, from Myristica fragrans Houtt., exhibiting PARP-1 and NF-κB inhibitory effects. Food Chem 202:269-275
• Cao G-Y, Xu W, Yang X-W, Gonzalez FJ, Li F (2015) New neolignans from the seeds of Myristica fragrans that inhibit nitric oxide production. Food Chem 173:231-237
• Morikawa T, Hachiman I, Matsuo K, Nishida E, Ninomiya K, Hayakawa T, Yoshie O, Muraoka O, Nakayama T (2016) Neolignans from the arils of Myristica fragrans as potent antagonists of CC chemokine receptor 3. J Nat Prod 79:2005-2013

Terms in the title (8)： 抗原刺激 ,  ラット ,  好塩基球性 ,  白血病細胞 ,  Myristica ,  種皮 ,  脱顆粒 ,  阻害剤