Art

J-GLOBAL ID：201802216031464128   Reference number：18A0995981

A new strategy to identify hepatitis B virus entry inhibitors by AlphaScreen technology targeting the envelope-receptor interaction

エンベロープ-受容体相互作用を標的とするAlphascreen技術によるB型肝炎ウイルス侵入阻害剤を同定する新しい戦略【JST・京大機械翻訳】

Author (24)： Saso Wakana (Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan) ,  Saso Wakana (AIDS Research Center, National Institute of Infectious Diseases, Tokyo, Japan) ,  Saso Wakana (The Institute of Medical Science, The University of Tokyo, Tokyo, Japan) ,  Tsukuda Senko (Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan) ,  Tsukuda Senko (Liver Cancer Prevention Research Unit, RIKEN Center for Integrative Medical Sciences (IMS), Wako, Japan) ,  Ohashi Hirofumi (Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan) ,  Ohashi Hirofumi (Department of Applied Biological Sciences, Tokyo University of Science, Noda, Japan) ,  Fukano Kento (Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan) ,  Fukano Kento (Department of Analytical Biochemistry, Meiji Pharmaceutical University, Kiyose, Japan) ,  Morishita Ryo (CellFree Sciences Co., Ltd., Matsuyama, Japan) ,  Matsunaga Satoko (Department of Microbiology, Yokohama City University Graduate School of Medicine, Yokohama, Japan) ,  Ohki Mio (Drug Design Laboratory, Graduate School of Medical Life Science, Yokohama City University, Yokohama, Japan) ,  Ryo Akihide (Department of Microbiology, Yokohama City University Graduate School of Medicine, Yokohama, Japan) ,  Park Sam-Yong (Drug Design Laboratory, Graduate School of Medical Life Science, Yokohama City University, Yokohama, Japan) ,  Suzuki Ryosuke (Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan) ,  Aizaki Hideki (Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan) ,  Muramatsu Masamichi (Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan) ,  Sureau Camille (Laboratoire de Virologie Moleculaire, Institut National de la Transfusion Sanguine, INSERM U1134, Paris, France) ,  Wakita Takaji (Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan) ,  Matano Tetsuro (AIDS Research Center, National Institute of Infectious Diseases, Tokyo, Japan) ,  Matano Tetsuro (The Institute of Medical Science, The University of Tokyo, Tokyo, Japan) ,  Watashi Koichi (Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan) ,  Watashi Koichi (Department of Applied Biological Sciences, Tokyo University of Science, Noda, Japan) ,  Watashi Koichi (CREST, JST, Saitama, Japan)
Material： Biochemical and Biophysical Research Communications  (BBRC)
Volume： 501  Issue： 2  Page： 374-379  Publication year： 2018 
JST Material Number： B0118A  ISSN： 0006-291X  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Current anti-hepatitis B virus...

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Thesaurus term： pretreatment ,  *Viruses ,  polypeptide ,  small molecule ,  cytotoxicity ,  immunosuppressant ,  hepatocyte ,  *receptor ,  infection ,  screening (inspection) ,  *interaction ,  adhesion (surface chemistry) ,  sensitivity ,  *invasion ,  *microorganism ,  ether ,  macrocyclic compound ,  lactam ,  lactone ,  enzyme inhibitor ,  hemiacetal ,  alicyclic alcohol ,  secondary alcohol ,  hydroxy ketone

Author keywords (6)： HBV ,  AlphaScreen ,  NTCP ,  Rapamycin ,  Entry ,  Screening

JST classification (2)： Physiology and pathogenicity of virus infection  (EG04042Y) ,  Biological function  (EB03040U)

Substance index (1)： Sirolimus

Terms in the title (8)： エンベロープ ,  受容体 ,  相互作用 ,  標的 ,  B型肝炎ウイルス ,  侵入阻害剤 ,  同定 ,  戦略