Art

J-GLOBAL ID：201802219897710364   Reference number：18A0729573

Identification of somatic mutations in postmortem human brains by whole genome sequencing and their implications for psychiatric disorders

全ゲノム配列決定による死後ヒト脳における体細胞突然変異の同定と精神障害に対するそれらの意味

Author (21)： Nishioka Masaki (Department of Molecular Psychiatry, The University of Tokyo, Tokyo, Japan) ,  Nishioka Masaki (Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan) ,  Nishioka Masaki (Division for Counseling and Support, The University of Tokyo, Tokyo, Japan) ,  Bundo Miki (Department of Molecular Psychiatry, The University of Tokyo, Tokyo, Japan) ,  Bundo Miki (PRESTO, Japan Science and Technology Agency, Saitama, Japan) ,  Bundo Miki (Department of Molecular Brain Science, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan) ,  Ueda Junko (Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Saitama, Japan) ,  Katsuoka Fumiki (Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan) ,  Sato Yukuto (Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan) ,  Kuroki Yoko (Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan) ,  Kuroki Yoko (Department of Genome Medicine, National Research Institute for Child Health and Development, Tokyo, Japan) ,  Ishii Takao (Department of Neuropsychiatry, School of Medicine, Sapporo Medical University, Sapporo, Japan) ,  Ukai Wataru (Department of Neuropsychiatry, School of Medicine, Sapporo Medical University, Sapporo, Japan) ,  Murayama Shigeo (Department of Neuropathology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan) ,  Hashimoto Eri (Department of Neuropsychiatry, School of Medicine, Sapporo Medical University, Sapporo, Japan) ,  Nagasaki Masao (Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan) ,  Yasuda Jun (Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan) ,  Kasai Kiyoto (Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan) ,  Kato Tadafumi (Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Saitama, Japan) ,  Iwamoto Kazuya (Department of Molecular Psychiatry, The University of Tokyo, Tokyo, Japan) ,  Iwamoto Kazuya (Department of Molecular Brain Science, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan)
Material： Psychiatry and Clinical Neurosciences  (Psychiatry Clin Neurosci)
Volume： 72  Issue： 4  Page： 280-294  Publication year： Apr. 2018 
JST Material Number： W1032A  ISSN： 1323-1316  Document type： Article
Article type： 原著論文  Country of issue： Australia (AUS)  Language： ENGLISH (EN)

Thesaurus term： human(primates) ,...
Semi thesaurus term： CpG ,...

Register(free) or Log In to access     To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=18A0729573&from=J-GLOBAL&jstjournalNo=W1032A") }}

Author keywords (5)： human brain ,  neuron ,  psychiatric disorder ,  somatic mutation ,  whole genome sequencing

JST classification (3)： Genetic variation  (EC01030Y) ,  Mental disorders  (GR03000A) ,  Neurology in general  (GN01010L)

Terms in the title (7)： ゲノム配列 ,  ヒト ,  脳 ,  体細胞突然変異 ,  同定 ,  精神障害 ,  意味