Art

J-GLOBAL ID：201802220338206053   Reference number：18A0262820

Non-neoplastic lesions found only in the two-year bioassays but not in shorter toxicity studies of rats

ラットの短い毒性試験ではなく2年間のバイオアッセイでのみ発見された非腫瘍性病変【Powered by NICT】

Author (7)： Nonaka Mizuho (Pharmaceuticals and Medical Devices Agency, 3-3-2 Kasumigaseki, Chiyoda-ku, Tokyo 100-0013, Japan) ,  Amakasu Kouhei (Pharmaceuticals and Medical Devices Agency, 3-3-2 Kasumigaseki, Chiyoda-ku, Tokyo 100-0013, Japan) ,  Saegusa Yukie (Pharmaceuticals and Medical Devices Agency, 3-3-2 Kasumigaseki, Chiyoda-ku, Tokyo 100-0013, Japan) ,  Naota Misaki (Pharmaceuticals and Medical Devices Agency, 3-3-2 Kasumigaseki, Chiyoda-ku, Tokyo 100-0013, Japan) ,  Nishimura Takuya (Pharmaceuticals and Medical Devices Agency, 3-3-2 Kasumigaseki, Chiyoda-ku, Tokyo 100-0013, Japan) ,  Ogawa Kumiko (Biological Safety Research Center, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan) ,  Nishikawa Akiyoshi (Biological Safety Research Center, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan)
Material： Regulatory Toxicology and Pharmacology  (Regul Toxicol Pharmacol)
Volume： 86  Page： 199-204  Publication year： 2017 
JST Material Number： T0249A  ISSN： 0273-2300  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： International Conference on Ha...

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Thesaurus term： carcinogenicity ,  pharmaceutical preparation ,  forecast ,  Japan ,  pharmacological action ,  *bioassay ,  chronic toxicity ,  *toxicity test ,  Risk Management ,  international conference ,  human ,  Toxicity Tests, Chronic ,  Carcinogenicity Tests
Semi thesaurus term： *病巣 ,  病理組織学 , 【Automatic Indexing@JST】

Author keywords (4)： Non-neoplastic lesion ,  Carcinogenicity study ,  ICH ,  Rat

JST classification (2)： Carcinogenic mechanisms and factors  (GE02020C) ,  Toxicity of organic compounds  (GZ02030Y)

Terms in the title (5)： ラット ,  毒性試験 ,  バイオアッセイ ,  発見 ,  腫瘍性病変