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J-GLOBAL ID：201802221372721707   Reference number：18A0664302

Alzheimer’s disease pathology in Nasu-Hakola disease brains

那須-ハコラ病脳におけるアルツハイマー病の病理

Author (4)： Satoh Jun-ichi (Department of Bioinformatics and Molecular Neuropathology, Meiji Pharmaceutical University) ,  Kino Yoshihiro (Department of Bioinformatics and Molecular Neuropathology, Meiji Pharmaceutical University) ,  Yanaizu Motoaki (Department of Bioinformatics and Molecular Neuropathology, Meiji Pharmaceutical University) ,  Saito Yuko (Department of Laboratory Medicine, National Center Hospital, NCNP)
Material： Intractable & Rare Diseases Research  (IRDR)
Volume： 7  Issue： 1  Page： 32-36(J-STAGE)  Publication year： 2018 
JST Material Number： F1228A  ISSN： 2186-3644  CODEN： IRDRA3  Document type： Article
Article type： 短報  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *hereditary disease ,...
Semi thesaurus term： *Nasu-Hakola disease

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Author keywords (4)： Alzheimer’s disease ,  amyloid-β ,  Nasu-Hakola disease ,  phosphorylated tau

JST classification (2)： Neurologic diagnosis  (GN02000H) ,  Diagnostics of congenital diseases, deformities.  (GD03020G)

Reference (21)：

• 1. Klünemann HH, Ridha BH, Magy L, Wherrett JR, Hemelsoet DM, Keen RW, De Bleecker JL, Rossor MN, Marienhagen J, Klein HE, Peltonen L, Paloneva J. The genetic causes of basal ganglia calcification, dementia, and bone cysts: DAP12 and TREM2. Neurology. 2005; 64:1502-1507.
• 2. Bianchin MM, Capella HM, Chaves DL, Steindel M, Grisard EC, Ganev GG, da Silva Júnior JP, Neto Evaldo S, Poffo MA, Walz R, Carlotti Júnior CG, Sakamoto AC. Nasu-Hakola disease (polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy - PLOSL): A dementia associated with bone cystic lesions. From clinical to genetic and molecular aspects. Cell Mol Neurobiol. 2004; 24:1-24.
• 3. Satoh J, Tabunoki H, Ishida T, Yagishita S, Jinnai K, Futamura N, Kobayashi M, Toyoshima I, Yoshioka T, Enomoto K, Arai N, Arima K. Immunohistochemical characterization of microglia in Nasu-Hakola disease brains. Neuropathology. 2011; 31:363-375.
• 4. Wang Y, Cella M, Mallinson K, Ulrich JD, Young KL, Robinette ML, Gilfillan S, Krishnan GM, Sudhakar S, Zinselmeyer BH, Holtzman DM, Cirrito JR, Colonna M. TREM2 lipid sensing sustains the microglial response in an Alzheimer's disease model. Cell. 2015; 160:1061-1071.
• 5. Yeh FL, Wang Y, Tom I, Gonzalez LC, Sheng M. TREM2 binds to apolipoproteins, including APOE and CLU/APOJ, and thereby facilitates uptake of amyloid-beta by microglia. Neuron. 2016; 91:328-340.

Terms in the title (4)： 那須-ハコラ病 ,  脳 ,  アルツハイマー病 ,  病理