Art

J-GLOBAL ID：201802221663423970   Reference number：18A0827492

Reduction of Membrane Protein CRIM1 Decreases E-Cadherin and Increases Claudin-1 and MMPs, Enhancing the Migration and Invasion of Renal Carcinoma Cells

膜蛋白質CRIM1の減少はE-カドヘリンを減少させ,Claudin-1を増加させ,腎臓腫瘍細胞の移動と浸潤を増強する

Author (9)： Ogasawara Nobutaka (Department of Health Chemistry, School of Pharmacy, Iwate Medical University) ,  Kudo Tamami (Department of Health Chemistry, School of Pharmacy, Iwate Medical University) ,  Sato Masaki (Department of Health Chemistry, School of Pharmacy, Iwate Medical University) ,  Kawasaki Yasushi (Department of Health Chemistry, School of Pharmacy, Iwate Medical University) ,  Yonezawa Sei (Department of Health Chemistry, School of Pharmacy, Iwate Medical University) ,  Takahashi Satoru (Department of Immunobiology, School of Pharmacy and Pharmaceutical Science, Mukogawa Women’s University) ,  Miyagi Yohei (Division of Molecular Pathology and Genetics, Kanagawa Cancer Center Research Institute) ,  Natori Yasuhiro (Department of Health Chemistry, School of Pharmacy, Iwate Medical University) ,  Sugiyama Akinori (Department of Health Chemistry, School of Pharmacy, Iwate Medical University)
Material： Biological and Pharmaceutical Bulletin (Web)
Volume： 41  Issue： 4  Page： 604-611(J-STAGE)  Publication year： 2018 
JST Material Number： U1402A  ISSN： 1347-5215  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： human(primates) ,...
Semi thesaurus term： *CRIM1 ,...

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Author keywords (10)： CRIM1 ,  E-cadherin ,  epithelial-mesenchymal transition ,  claudin-1 ,  tumor necrosis factor alpha ,  CRIM1 ,  E-cadherin ,  epithelial-mesenchymal transition ,  claudin-1 ,  tumor necrosis factor alpha

JST classification (3)： Urogenital tumors(=neoplasms)  (GM04000S) ,  Chemistry,biochemistry and pathology of tumors(=neoplasms)  (GE02030N) ,  Cell physiology in general  (EF02010S)

Reference (32)：

• 1) Kolle G, Georgas K, Holmes GP, Little MH, Yamada T. CRIM1, a novel gene encoding a cysteine-rich repeat protein, is developmentally regulated and implicated in vertebrate CNS development and organogenesis. Mech. Dev., 90, 181-193 (2000).
• 2) Lovicu FJ, Kolle G, Yamada T, Little MH, McAvoy JW. Expression of Crim1 during murine ocular development. Mech. Dev., 94, 261-265 (2000).
• 3) Georgas K, Bowles J, Yamada T, Koopman P, Little MH. Characterization of Crim1 expression in the developing mouse urogenital tract reveals a sexually dimorphic gonadal expression pattern. Dev. Dyn., 219, 582-587 (2000).
• 4) Nyström J, Hultenby K, Ek S, Sjölund J, Axelson H, Jirström K, Saleem MA, Nilsson K, Johansson ME. CRIM1 is localized to the podocyte filtration slit diaphragm of the adult human kidney. Nephrol. Dial. Transplant., 24, 2038-2044 (2009).
• 5) Pennisi DJ, Wilkinson L, Kolle G, Sohaskey ML, Gillinder K, Piper MJ, McAvoy JW, Lovicu FJ, Little MH. Crim1KST264/KST264 mice display a disruption of the Crim1 gene resulting in perinatal lethality with defects in multiple organ systems. Dev. Dyn., 236, 502-511 (2007).

Terms in the title (6)： 膜蛋白質 ,  E-カドヘリン ,  腎臓 ,  腫瘍細胞 ,  浸潤 ,  増強