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J-GLOBAL ID：201802222098708965   Reference number：18A0831376

Glutathione has a more important role than metallothionein-I/II against inorganic mercury-induced acute renal toxicity

グルタチオンは無機水銀による急性腎障害に対してメタロチオネイン-I/IIより重要な役割を持つ

Author (8)： Tokumoto Maki (Laboratory of Pharmaceutical Health Sciences, School of Pharmacy, Aichi Gakuin University) ,  Lee Jin-Yong (Laboratory of Pharmaceutical Health Sciences, School of Pharmacy, Aichi Gakuin University) ,  Shimada Akinori (Laboratory of Pathology, Department of Medical Technology, School of Life and Environmental Science, Azabu University) ,  Tohyama Chiharu (Faculty of Medicine, University of Tsukuba) ,  Tohyama Chiharu (National Institute for Environmental Studies) ,  Tohyama Chiharu (Program of Environmental Toxicology, School of Public Health, China Medical University) ,  Satoh Masahiko (Laboratory of Pharmaceutical Health Sciences, School of Pharmacy, Aichi Gakuin University) ,  Satoh Masahiko (National Institute for Environmental Studies)
Material： Journal of Toxicological Sciences  (J Toxicol Sci)
Volume： 43  Issue： 4  Page： 275-280(J-STAGE)  Publication year： 2018 
JST Material Number： Z0265B  ISSN： 0388-1350  Document type： Article
Article type： 短報  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： kidney disease ,...
Semi thesaurus term： *Metallothionein I ,...

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Author keywords (4)： Inorganic mercury ,  Metallothionein ,  Glutathione ,  Nephrotoxicity

JST classification (2)： Toxicity of metals and metal compounds  (GZ02022V) ,  Basic medicine on urogenital system  (GM01020T)

Substance index (2)： L-Buthionine sulfoximine ,  Glutathione

Reference (25)：

• Bohets, H.H., Van Thielen, M.N., Van der Biest, I., Van Landeghem, G.F., D’Haese, P.C., Nouwen, E.J., De Broe, M.E. and Dierickx, P.J. (1995): Cytotoxicity of mercury compounds in LLC-PK1, MDCK and human proximal tubular cells. Kidney Int., 47, 395-403.
• Bose-O’Reilly, S., Bernaudat, L., Siebert, U., Roider, G., Nowak, D. and Drasch, G. (2017): Signs and symptoms of mercury-exposed gold miners. Int. J. Occup. Med. Environ. Health, 30, 249-269.
• Chan, H.M., Satoh, M., Zalups, R.K. and Cherian, M.G. (1992): Exogenous metallothionein and renal toxicity of cadmium and mercury in rats. Toxicology, 76, 15-26.
• Cherian, M.G. (1977): Studies on the synthesis and metabolism of zinc-thionein in rats. J. Nutr., 107, 965-972.
• Davies, M.H., Bozigian, H.P., Merrick, B.A., Birt, D.F. and Schnell, R.C. (1983): Circadian variations in glutathione-S-transferase and glutathione peroxidase activities in the mouse. Toxicol. Lett., 19, 23-27.

Terms in the title (5)： グルタチオン ,  無機水銀 ,  急性腎障害 ,  メタロチオネイン ,  役割