Art

J-GLOBAL ID：201802223804748001   Reference number：18A2157638

Relationship Between Thymidine Kinase 1 Expression and Trifluridine/Tipiracil Therapy in Refractory Metastatic Colorectal Cancer: A Pooled Analysis of 2 Randomized Clinical Trials

難治性転移性結腸直腸癌におけるチミジンキナーゼ1発現とトリフルリジン/チピラシル療法の間の関係:2つの無作為化臨床試験のプール分析【JST・京大機械翻訳】

Author (24)： Yoshino Takayuki (Department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, Kashiwa, Japan) ,  Yamazaki Kentaro (Division of Gastrointestinal Oncology, Shizuoka Cancer Center, Shizuoka, Japan) ,  Shinozaki Eiji (Department of Gastroenterology Cancer, Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan) ,  Komatsu Yoshito (Department of Cancer Chemotherapy, Hokkaido University Hospital, Sapporo, Japan) ,  Nishina Tomohiro (Department of Gastrointestinal Medical Oncology, National Hospital Organization Shikoku Cancer Center, Matsuyama, Japan) ,  Baba Hideo (Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan) ,  Tsuji Akihito (Department of Clinical Oncology, Kochi Health Sciences Center, Kochi, Japan) ,  Tsuji Akihito (Department of Clinical Oncology, Kobe City Medical Center General Hospital, Kobe, Japan) ,  Tsuji Yasushi (Department of Medical Oncology, Tonan Hospital, Sapporo, Japan) ,  Yamaguchi Kensei (Department of Gastroenterology, Saitama Cancer Center, Saitama, Japan) ,  Sugimoto Naotoshi (Department of Medical Oncology, Osaka International Cancer Institute, Osaka, Japan) ,  Denda Tadamichi (Division of Gastroenterology, Chiba Cancer Center, Chiba, Japan) ,  Muro Kei (Department of Clinical Oncology, Aichi Cancer Center Hospital, Nagoya, Japan) ,  Takayama Tetsuji (Department of Gastroenterology and Oncology, University of Tokushima, Tokushima, Japan) ,  Esaki Taito (Department of Gastrointestinal and Medical Oncology, National Hospital Organization, Kyushu Cancer Center, Fukuoka, Japan) ,  Hamamoto Yasuo (Department of Chemotherapy, Tochigi Cancer Center, Tochigi, Japan) ,  Hamamoto Yasuo (Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan) ,  Moriwaki Toshikazu (Division of Gastroenterology, University of Tsukuba, Tsukuba, Japan) ,  Shimada Yasuhiro (Gastrointestinal Oncology Division, National Cancer Center Hospital, Tokyo, Japan) ,  Goto Masahiro (Cancer Chemotherapy Center, Osaka Medical College Hospital, Osaka, Japan) ,  Nakayama Norisuke (Department of Gastroenterology, Kanagawa Cancer Center, Yokohama, Japan) ,  Fujii Hirofumi (Department of Clinical Oncology, Jichi Medical University Hospital, Tochigi, Japan) ,  Tanase Takanori (Taiho Pharmaceutical Co Ltd, Tokyo, Japan) ,  Ohtsu Atsushi (Department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, Kashiwa, Japan)
Material： Clinical Colorectal Cancer
Volume： 17  Issue： 4  Page： e719-e732  Publication year： 2018 
JST Material Number： W3205A  ISSN： 1533-0028  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： High thymidine kinase 1 (TK1) ...

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Thesaurus term： effectiveness ,  survival ratio ,  forecast ,  *Thymidine Kinase ,  DNA ,  *randomized controlled trial ,  placebo ,  antitumor action ,  tumor ,  Prognosis ,  drug therapy ,  confidence interval ,  biomarker
Semi thesaurus term： ハザード比 ,  カットオフ ,  *転移性大腸癌 , 【Automatic Indexing@JST】

Author keywords (5)： Biomarker ,  Disease control rate ,  Next-generation sequencing ,  Overall survival ,  Progression-free survival

JST classification (2)： Clinical application of antitumor(=antineoplastic)drugs  (GW16020L) ,  Drug therapy(=pharmacotherapy)for tumors  (GE03032C)

Terms in the title (7)： 転移性結腸直腸癌 ,  チミジンキナーゼ ,  発現 ,  トリフルリジン ,  療法 ,  無作為化臨床試験 ,  分析