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J-GLOBAL ID：201802223907915877   Reference number：18A0336645

Divergent synthesis of kinase inhibitor derivatives, leading to discovery of selective Gck inhibitors

キナーゼ阻害剤誘導体,選択的Gck阻害剤の発見への分岐合成【Powered by NICT】

Author (13)： Matsumaru Takanori (Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, Japan) ,  Inai Makoto (School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan) ,  Ishigami Kana (School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan) ,  Iwamatsu Toshiki (Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, Japan) ,  Maita Hiroshi (Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, Japan) ,  Otsuguro Satoko (Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, Japan) ,  Nomura Takao (Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, Japan) ,  Matsuda Akira (Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, Japan) ,  Ichikawa Satoshi (Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, Japan) ,  Sakaitani Masahiro (Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, Japan) ,  Shuto Satoshi (Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, Japan) ,  Maenaka Katsumi (Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, Japan) ,  Kan Toshiyuki (School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan)
Material： Bioorganic & Medicinal Chemistry Letters  (Bioorg Med Chem Lett)
Volume： 27  Issue： 10  Page： 2144-2147  Publication year： 2017 
JST Material Number： W0248A  ISSN： 0960-894X  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： We accomplished divergent synt...

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Thesaurus term： *cross coupling reaction ,  conjugation ,  palladium catalyst ,  *kinase ,  *Protein Kinase Inhibitors ,  nitrogen heterocyclic compound ,  polynuclear aromatic compound
Semi thesaurus term： *阻害剤 , 【Automatic Indexing@JST】

Author keywords (5)： BAY 61-3606 ,  Imidazo[12-c]pyrimidine ,  Gck ,  Indole ,  Kinase inhibitor

JST classification (1)： Structure-activity relationship of drugs  (GV01050B)

Substance index (2)： Indole ,  Pyridine

Terms in the title (5)： キナーゼ阻害剤 ,  誘導体 ,  阻害剤 ,  発見 ,  分岐