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J-GLOBAL ID：201802224494454577   Reference number：18A1619433

Muscarinic Acetylcholine Receptors Chrm1 and Chrm3 Are Essential for REM Sleep

ムスカリン性アセチルコリン受容体CHRM1とCHRM3はREM睡眠に必須である【JST・京大機械翻訳】

Author (31)： Niwa Yasutaka (Laboratory for Synthetic Biology, RIKEN Center for Biosystems Dynamics Research, 1-3 Yamadaoka, Suita, Osaka 565-0871, Japan) ,  Niwa Yasutaka (International Institute for Integrative Sleep Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan) ,  Kanda Genki N. (Laboratory for Synthetic Biology, RIKEN Center for Biosystems Dynamics Research, 1-3 Yamadaoka, Suita, Osaka 565-0871, Japan) ,  Kanda Genki N. (Graduate School of Frontier Biosciences, Osaka University, 1-3 Yamadaoka, Suita, Osaka 565-0871, Japan) ,  Kanda Genki N. (Laboratory for Retinal Regeneration, RIKEN Center for Biosystems Dynamics Research, 2-2-3 Minatojima Minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan) ,  Yamada Rikuhiro G. (Laboratory for Synthetic Biology, RIKEN Center for Biosystems Dynamics Research, 1-3 Yamadaoka, Suita, Osaka 565-0871, Japan) ,  Shi Shoi (Laboratory for Synthetic Biology, RIKEN Center for Biosystems Dynamics Research, 1-3 Yamadaoka, Suita, Osaka 565-0871, Japan) ,  Shi Shoi (Department of Systems Pharmacology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan) ,  Shi Shoi (International Research Center for Neurointelligence (WPI-IRCN), The University of Tokyo Institutes for Advanced Study (UTIAS), The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan) ,  Sunagawa Genshiro A. (Laboratory for Synthetic Biology, RIKEN Center for Biosystems Dynamics Research, 1-3 Yamadaoka, Suita, Osaka 565-0871, Japan) ,  Sunagawa Genshiro A. (Laboratory for Retinal Regeneration, RIKEN Center for Biosystems Dynamics Research, 2-2-3 Minatojima Minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan) ,  Ukai-Tadenuma Maki (Laboratory for Synthetic Biology, RIKEN Center for Biosystems Dynamics Research, 1-3 Yamadaoka, Suita, Osaka 565-0871, Japan) ,  Ukai-Tadenuma Maki (International Research Center for Neurointelligence (WPI-IRCN), The University of Tokyo Institutes for Advanced Study (UTIAS), The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan) ,  Fujishima Hiroshi (Laboratory for Synthetic Biology, RIKEN Center for Biosystems Dynamics Research, 1-3 Yamadaoka, Suita, Osaka 565-0871, Japan) ,  Matsumoto Naomi (Laboratory for Mouse Genetic Engineering, RIKEN Center for Biosystems Dynamics Research, 1-3 Yamadaoka, Suita, Osaka 565-0871, Japan) ,  Masumoto Koh-hei (Department of Anatomy and Neurobiology, Kindai University Faculty of Medicine, 377-2 Ohno-Higashi, Osakasayama City, Osaka 589-8511, Japan) ,  Masumoto Koh-hei (Center for Medical Science, International University of Health and Welfare, 2600-1 Kitakanemaru, Ohtawara, Tochigi 324-8501, Japan) ,  Masumoto Koh-hei (Division of Neuroanatomy, Department of Neuroscience, Yamaguchi University Graduate School of Medicine, 1-1-1 Mianmi-Kogushi, Ube, Yamaguchi 755-8505, Japan) ,  Nagano Mamoru (Department of Anatomy and Neurobiology, Kindai University Faculty of Medicine, 377-2 Ohno-Higashi, Osakasayama City, Osaka 589-8511, Japan) ,  Kasukawa Takeya (Large Scale Data Managing Unit, RIKEN Center for Integrative Medical Sciences, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan) ,  Galloway James (School of Electrical Engineering and Computer Science, Queensland University of Technology, GPO Box 2434, Brisbane, QLD 4001, Australia) ,  Perrin Dimitri (Laboratory for Synthetic Biology, RIKEN Center for Biosystems Dynamics Research, 1-3 Yamadaoka, Suita, Osaka 565-0871, Japan) ,  Perrin Dimitri (School of Electrical Engineering and Computer Science, Queensland University of Technology, GPO Box 2434, Brisbane, QLD 4001, Australia) ,  Shigeyoshi Yasufumi (Department of Anatomy and Neurobiology, Kindai University Faculty of Medicine, 377-2 Ohno-Higashi, Osakasayama City, Osaka 589-8511, Japan) ,  Ukai Hideki (Laboratory for Synthetic Biology, RIKEN Center for Biosystems Dynamics Research, 1-3 Yamadaoka, Suita, Osaka 565-0871, Japan) ,  Ukai Hideki (International Research Center for Neurointelligence (WPI-IRCN), The University of Tokyo Institutes for Advanced Study (UTIAS), The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan) ,  Kiyonari Hiroshi (Animal Resource Development Unit and Genetic Engineering Team, RIKEN Center for Biosystems Dynamics Research, 2-2-3 Minatojima Minami-machi, Chuo-ku, Kobe, Hyogo 650-0047, Japan) ,  Sumiyama Kenta (Laboratory for Mouse Genetic Engineering, RIKEN Center for Biosystems Dynamics Research, 1-3 Yamadaoka, Suita, Osaka 565-0871, Japan) ,  Ueda Hiroki R. (Laboratory for Synthetic Biology, RIKEN Center for Biosystems Dynamics Research, 1-3 Yamadaoka, Suita, Osaka 565-0871, Japan) ,  Ueda Hiroki R. (Department of Systems Pharmacology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan) ,  Ueda Hiroki R. (International Research Center for Neurointelligence (WPI-IRCN), The University of Tokyo Institutes for Advanced Study (UTIAS), The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan)
Material： Cell Reports
Volume： 24  Issue： 9  Page： 2231-2247.e7  Publication year： 2018 
JST Material Number： W3124A  ISSN： 2211-1247  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Sleep regulation involves inte...

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Thesaurus term： *REM sleep ,  cellular signal transduction ,  redundancy(property) ,  neuron ,  gene ,  duration time ,  synapse ,  phenotype ,  shake out ,  *muscarinic receptor ,  *acetylcholine receptor ,  aliphatic amine ,  aliphatic alcohol ,  quaternary ammonium ,  aminoalcohol ,  fatty acid
Semi thesaurus term： 暗期 ,  trkA受容体 , 【Automatic Indexing@JST】

Author keywords (9)： acetylcholine ,  sleep ,  REM sleep ,  Chrm1 ,  Chrm3 ,  tTR ,  TrkA ,  triple-target CRISPR ,  Tet system

JST classification (3)： Receptors on cell membrane  (EF04030C) ,  Basic neurology  (GN01020W) ,  Central nervous system  (EJ12030F)

Substance index (2)： Choline ,  Acetylcholine

Terms in the title (2)： ムスカリン性アセチルコリン受容体 ,  REM睡眠