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J-GLOBAL ID：201802225886038971   Reference number：18A1814432

Mitochondrial Stasis Reveals p62-Mediated Ubiquitination in Parkin-Independent Mitophagy and Mitigates Nonalcoholic Fatty Liver Disease

ミトコンドリア静止はパーキン非依存性マイトファジーにおけるp62仲介ユビキチン化を明らかにし,非アルコール性脂肪肝疾患を緩和する【JST・京大機械翻訳】

Author (17)： Yamada Tatsuya (Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA) ,  Murata Daisuke (Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA) ,  Adachi Yoshihiro (Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA) ,  Itoh Kie (Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA) ,  Kameoka Shoichiro (Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA) ,  Kameoka Shoichiro (Graduate School of Frontier Biosciences, Osaka University, Osaka 565-0871, Japan) ,  Igarashi Atsushi (Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA) ,  Kato Takashi (Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA) ,  Araki Yoichi (Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA) ,  Huganir Richard L. (Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA) ,  Dawson Ted M. (Departments of Neurology and Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA) ,  Dawson Ted M. (Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA) ,  Dawson Ted M. (Adrienne Helis Malvin Medical Research Foundation, New Orleans, LA 70130, USA) ,  Yanagawa Toru (Department of Oral and Maxillofacial Surgery, Faculty of Medicine, University of Tsukuba, Ibaraki 305-8575, Japan) ,  Okamoto Koji (Graduate School of Frontier Biosciences, Osaka University, Osaka 565-0871, Japan) ,  Iijima Miho (Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA) ,  Sesaki Hiromi (Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA)
Material： Cell Metabolism
Volume： 28  Issue： 4  Page： 588-604.e5  Publication year： 2018 
JST Material Number： W3108A  ISSN： 1550-4131  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： It is unknown what occurs if b...

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Thesaurus term： GTPase ,  *mitochondria ,  *ubiquitination ,  adaptor protein ,  complex(substance) ,  autophagy ,  *fatty liver ,  experimental disease
Semi thesaurus term： Keap1蛋白質 ,  ダイナミン ,  Drp1 ,  ミトコンドリア分裂 ,  *p62 ,  *マイトファジー ,  *Parkin , 【Automatic Indexing@JST】

Author keywords (10)： mitochondria ,  mitochondrial fission ,  mitochondrial fusion ,  mitophagy ,  dynamin-related GTPase ,  Drp1 ,  Opa1 ,  mitochondrial division ,  fatty liver ,  nonalcoholic steatohepatitis

JST classification (3)： Biological function  (EB03040U) ,  Basic neurology  (GN01020W) ,  Cell components in general  (EF03010Z)

Terms in the title (10)： ミトコンドリア ,  静止 ,  パーキン ,  非依存性 ,  マイトファジー ,  p62 ,  仲介 ,  ユビキチン化 ,  非アルコール性脂肪肝疾患 ,  緩和