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J-GLOBAL ID：201802225939299124   Reference number：18A0308014

Transcriptome Analysis Reveals That Midnolin Regulates mRNA Expression Levels of Multiple Parkinson’s Disease Causative Genes

トランスクリプトーム解析によりミドノリンはパーキンソン病の複数の原因遺伝子のmRNA発現レベルを制御することが明らかになる

Author (2)： Obara Yutaro (Department of Pharmacology, Yamagata University School of Medicine) ,  Ishii Kuniaki (Department of Pharmacology, Yamagata University School of Medicine)
Material： Biological and Pharmaceutical Bulletin  (Biological & Pharmaceutical Bulletin)
Volume： 41  Issue： 1  Page： 20-23(J-STAGE)  Publication year： 2018 
JST Material Number： S0989A  ISSN： 0918-6158  CODEN： BPBLEO  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： human ,...
Semi thesaurus term： EIF4G1 ,...

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Author keywords (8)： midnolin (MIDN) ,  Parkinson’s disease (PD) ,  transcriptome analysis ,  parkin ,  midnolin (MIDN) ,  Parkinson’s disease (PD) ,  transcriptome analysis ,  parkin

JST classification (3)： Basic neurology  (GN01020W) ,  Biological function  (EB03040U) ,  Molecular genetics in general  (EC02010J)

Reference (13)：

• 1) Ariga H. Common mechanisms of onset of cancer and neurodegenerative diseases. Biol. Pharm. Bull., 38, 795-808 (2015).
• 2) Ferreira M, Massano J. An updated review of Parkinson’s disease genetics and clinicopathological correlations. Acta Neurol. Scand., 135, 273-284 (2017).
• 3) Cieri D, Brini M, Cali T. Emerging (and converging) pathways in Parkinson’s disease: keeping mitochondrial wellness. Biochem. Biophys. Res. Commun., 483, 1020-1030 (2017).
• 4) Tsukahara M, Suemori H, Noguchi S, Ji ZS, Tsunoo H. Novel nucleolar protein, midnolin, is expressed in the mesencephalon during mouse development. Gene, 254, 45-55 (2000).
• 5) Hofmeister-Brix A, Kollmann K, Langer S, Schultz J, Lenzen S, Baltrusch S. Identification of the ubiquitin-like domain of midnolin as a new glucokinase interaction partner. J. Biol. Chem., 288, 35824-35839 (2013).

Terms in the title (4)： トランスクリプトーム解析 ,  パーキンソン病 ,  原因遺伝子 ,  mRNA発現