Art

J-GLOBAL ID：201802228865374822   Reference number：18A0610887

Feasibility of dose-dense epirubicin and cyclophosphamide with subcutaneous pegfilgrastim 3.6mg support: a single-center prospective study in Japan

皮下ペグフィルグラスチム3.6mgサポートでのエピルビシンおよびシクロホスファミド高用量投与の実行可能性:日本における単一施設前向き研究

Author (15)： MORITA Sachi (Nagoya Univ. Hospoital, Aichi, JPN) ,  KIKUMORI Toyone (Nagoya Univ. Hospoital, Aichi, JPN) ,  TSUNODA Nobuyuki (Nagoya Graduate School of Medicine, Aichi, JPN) ,  INAISHI Takahiro (Nagoya Univ. Hospoital, Aichi, JPN) ,  ADACHI Yayoi (Nagoya Univ. Hospoital, Aichi, JPN) ,  OTA Akiko (Nagoya Univ. Hospoital, Aichi, JPN) ,  SHIBATA Masahiro (Nagoya Univ. Hospoital, Aichi, JPN) ,  MATSUOKA Ayumu (Nagoya Univ. Hospoital, Aichi, JPN) ,  NAKANISHI Kenichi (Nagoya Univ. Hospoital, Aichi, JPN) ,  TAKEUCHI Dai (Nagoya Univ. Hospoital, Aichi, JPN) ,  MIZUTANI Takefumi (Nagoya Univ. Hospoital, Aichi, JPN) ,  SHIMOKATA Tomoya (Nagoya Univ. Hospoital, Aichi, JPN) ,  HAYASHI Hironori (Nagoya Univ. Hospoital, Aichi, JPN) ,  MAEDA Osamu (Nagoya Univ. Hospoital, Aichi, JPN) ,  ANDO Yuichi (Nagoya Univ. Hospoital, Aichi, JPN)
Material： International Journal of Clinical Oncology  (Int J Clin Oncol)
Volume： 23  Issue： 1  Page： 195-200  Publication year： Feb. 2018 
JST Material Number： L3966A  ISSN： 1341-9625  Document type： Article
Article type： 原著論文  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Thesaurus term： *anthracycline antibiotics ,...
Semi thesaurus term： *pegfilgrastim ,...

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JST classification (1)： Drug therapy(=pharmacotherapy)for tumors  (GE03032C)

Substance index (2)： Epirubicin ,  Cyclophosphamid

Reference (11)：

• Yamamoto N, Sekine I, Nakagawa K, et al. (2009) A pharmacokinetic and dose escalation study of pegfilgrastim (KRN 125) in lung cancer patients with chemotherapy-induced neutropenia. Jpn J Clin Oncol 39:425-430
• Green MD, Koelbl H, Baselga J, et al. (2003) A randomized double-blind multicenter phase III study of fixed-dose single-administration pegfilgrastim versus daily filgrastim in patients receiving myelosuppressive chemotherapy. Ann Oncol 14:29-35
• Holmes FA, Johnes SE, O’Shaughnessy J, et al. (2002) Comparable efficacy and safety profiles of once-per-cycle pegfilgrastim and daily injection filgrastim in chemotherapy-induced neutropenia: a multicenter dose-finding study in women with breast cancer. Ann Oncol 13:903-909
• Masuda N, Tokuda Y, Nakamura S, et al. (2015) Dose response of pegfilgrastim in Japanese breast cancer patients receiving six cycles of docetaxel, doxorubicin, and cyclophosphamide therapy: a randomized controlled trial. Support Care Cancer 23:2891-2898
• Del Mastro L, De Placido S, Bruzzi P, et al. (2015) Fluorouracil and dose- dense chemotherapy in adjuvant treatment of patients with early-stage breast cancer: an open-label, 2 × 2 factorial, randomized phase 3 trial. Lancet 385:1863-1872

Terms in the title (9)： ペグフィルグラスチム ,  エピルビシン ,  シクロホスファミド ,  高用量 ,  投与 ,  実行可能性 ,  日本 ,  施設 ,  研究