Art

J-GLOBAL ID：201802229600440740   Reference number：18A1005172

Leucine-rich alpha 2 glycoprotein promotes Th17 differentiation and collagen-induced arthritis in mice through enhancement of TGF-β-Smad2 signaling in naieve helper T cells

ロイシンに富むアルファ2糖蛋白質は,ナイーブヘルパーT細胞におけるTGF-β-Smad2シグナル伝達の増強を通してマウスにおけるTh17分化とコラーゲン誘発関節炎を促進する【JST・京大機械翻訳】

Author (12)： Urushima Hayato (Laboratory of Immune Signal, National Institutes of Biomedical Innovation, Health and Nutrition, Ibaraki, Japan) ,  Fujimoto Minoru (Laboratory of Immune Signal, National Institutes of Biomedical Innovation, Health and Nutrition, Ibaraki, Japan) ,  Fujimoto Minoru (Center for Intractable Immune Disease, Kochi Medical School, Kochi University, Kochi, Japan) ,  Mishima Takashi (Laboratory of Immune Signal, National Institutes of Biomedical Innovation, Health and Nutrition, Ibaraki, Japan) ,  Ohkawara Tomoharu (Laboratory of Immune Signal, National Institutes of Biomedical Innovation, Health and Nutrition, Ibaraki, Japan) ,  Honda Hiromi (Laboratory of Immune Signal, National Institutes of Biomedical Innovation, Health and Nutrition, Ibaraki, Japan) ,  Lee Hyun (Laboratory of Immune Signal, National Institutes of Biomedical Innovation, Health and Nutrition, Ibaraki, Japan) ,  Kawahata Hirohisa (Department of Medical Technology, Morinomiya University of medical science, Osaka, Japan) ,  Serada Satoshi (Laboratory of Immune Signal, National Institutes of Biomedical Innovation, Health and Nutrition, Ibaraki, Japan) ,  Serada Satoshi (Center for Intractable Immune Disease, Kochi Medical School, Kochi University, Kochi, Japan) ,  Naka Tetsuji (Laboratory of Immune Signal, National Institutes of Biomedical Innovation, Health and Nutrition, Ibaraki, Japan) ,  Naka Tetsuji (Center for Intractable Immune Disease, Kochi Medical School, Kochi University, Kochi, Japan)
Material： Arthritis Research & Therapy (Web)
Volume： 19  Issue： 1  Page： 137  Publication year： 2017 
JST Material Number： U7412A  ISSN： 1478-6362  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Abstract/Point： Background Leucine-rich alpha ...

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Thesaurus term： *differentiation(biology) ,  patient ,  rheumatoid arthritis ,  up-regulation ,  *TGF beta ,  pathogenesis ,  phosphorylation ,  *glycoprotein ,  interleukin 6 ,  regulatory T cell ,  pathological state ,  *T cell ,  CD4 antigen
Semi thesaurus term： *Th17細胞 ,  *Smad2蛋白質 , 【Automatic Indexing@JST】

Author keywords (5)： Leucine rich alpha2 glycoprotein ,  TGF-β ,  Smad2 ,  IL-6 receptor ,  Th17

JST classification (1)： Immunological reaction in general  (ED03010T)

Reference (45)：

• Ann Rheum Dis; iTRAQ-based proteomic identification of leucine-rich alpha-2 glycoprotein as a novel inflammatory biomarker in autoimmune diseases; S Serada, M Fujimoto, A Ogata, F Terabe, T Hirano, H Iijima, S Shinzaki, T Nishikawa, T Ohkawara, K Iwahori; 69; 4; 2010; 770-4; 10.1136/ard.2009.118919; CR1;
• Proc Natl Acad Sci U S A; Periodicity of leucine and tandem repetition of a 24-amino acid segment in the primary structure of leucine-rich alpha 2-glycoprotein of human serum; N Takahashi, Y Takahashi, FW Putnam; 82; 7; 1985; 1906-10; 10.1073/pnas.82.7.1906; CR2;
• Nature; LRG1 promotes angiogenesis by modulating endothelial TGF-beta signalling; X Wang, S Abraham, JA McKenzie, N Jeffs, M Swire, VB Tripathi, UF Luhmann, CA Lange, Z Zhai, HM Arthur; 499; 7458; 2013; 306-11; 10.1038/nature12345; CR3;
• Oncotarget; Leucine-rich alpha-2-glycoprotein promotes TGFbeta1-mediated growth suppression in the Lewis lung carcinoma cell lines; N Takemoto, S Serada, M Fujimoto, H Honda, T Ohkawara, T Takahashi, S Nomura, H Inohara, T Naka; 6; 13; 2015; 11009-22; 10.18632/oncotarget.3557; CR4;
• Cardiovasc Res; Myeloid cell-derived LRG attenuates adverse cardiac remodelling after myocardial infarction; S Kumagai, H Nakayama, M Fujimoto, H Honda, S Serada, H Ishibashi-Ueda, A Kasai, M Obana, Y Sakata, Y Sawa; 109; 2; 2016; 272-82; 10.1093/cvr/cvv273; CR5;

Terms in the title (13)： ロイシン ,  2糖 ,  蛋白質 ,  ヘルパーT細胞 ,  TGF-β ,  Smad2 ,  シグナル伝達 ,  増強 ,  マウス ,  Th17 ,  分化 ,  コラーゲン誘発関節炎 ,  促進