Art

J-GLOBAL ID：201802231952870090   Reference number：18A1198280

The CC chemokine ligand (CCL) 1, upregulated by the viral transactivator Tax, can be downregulated by minocycline: possible implications for long-term treatment of HTLV-1-associated myelopathy/tropical spastic paraparesis

ウイルス性トランス活性化因子Taxにより上方制御されるCCケモカイン配位子(CCL)1は,ミノサイクリンによりダウンレギュレーションされることができる:HTLV-1関連脊髄症/熱帯性痙性対麻痺の長期治療に対する可能な意味【JST・京大機械翻訳】

Author (9)： Saito Mineki (Department of Microbiology, Kawasaki Medical School, Okayama, Japan) ,  Sejima Hiroe (Department of Microbiology, Kawasaki Medical School, Okayama, Japan) ,  Naito Tadasuke (Department of Microbiology, Kawasaki Medical School, Okayama, Japan) ,  Ushirogawa Hiroshi (Department of Microbiology, Kawasaki Medical School, Okayama, Japan) ,  Matsuzaki Toshio (Department of Neurology and Geriatrics, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan) ,  Matsuura Eiji (Department of Neurology and Geriatrics, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan) ,  Tanaka Yuetsu (Department of Immunology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan) ,  Nakamura Tatsufumi (Department of Social Work, Faculty of Human and Social Studies, Nagasaki International University, Sasebo, Nagasaki, Japan) ,  Takashima Hiroshi (Department of Neurology and Geriatrics, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan)
Material： Virology Journal (Web)
Volume： 14  Issue： 1  Page： 234  Publication year： 2017 
JST Material Number： U7347A  ISSN： 1743-422X  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Abstract/Point： Chemokine (C-C motif) ligand 1...

Register(free) or Log In to access     To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=18A1198280&from=J-GLOBAL&jstjournalNo=U7347A") }}

Thesaurus term： adult (development) ,  *chemokine ,  promoter (genetics) ,  monocyte ,  regulatory T cell ,  *Down-Regulation ,  anti-inflammatory action ,  macrophage ,  Inflammation ,  pathogenesis ,  *spinal cord disease ,  infection ,  *Up-Regulation ,  Human T-cell leukemia virus type I ,  microorganism ,  leukovirus ,  animal virus ,  Oncovirus ,  HTLV ,  enol ,  aromatic amine ,  aromatic ketone ,  phenolic compound ,  carboxamide ,  enone ,  polynuclear aromatic compound ,  aminoalcohol ,  keto acid ,  diamine ,  diketone ,  tertiary amine ,  hydroxy acid ,  hydroxy ketone ,  polyol
Semi thesaurus term： HTLV1 , 【Automatic Indexing@JST】

Author keywords (5)： HTLV-1 ,  Tax ,  CCL1 ,  HAM/TSP ,  Minocycline

JST classification (2)： Infectious diseases,parasitics diseases in general.  (GD01010H) ,  Infectious immunity  (ED03030P)

Substance index (1)： Minocycline

Reference (39)：

• Proc Natl Acad Sci U S A; Monoclonal integration of human T-cell leukemia provirus in all primary tumors of adult T-cell leukemia suggests causative role of human T-cell leukemia virus in the disease; M Yoshida, M Seiki, K Yamaguchi, K Takatsuki; 81; 1984; 2534-2537; 10.1073/pnas.81.8.2534; citation_id=CR1
• Proc Natl Acad Sci U S A; Adult T-cell leukemia: antigen in an ATL cell line and detection of antibodies to the antigen in human sera; Y Hinuma, K Nagata, M Hanaoka, M Nakai, T Matsumoto, KI Kinoshita, S Shirakawa, I Miyoshi; 78; 1981; 6476-6480; 10.1073/pnas.78.10.6476; citation_id=CR2
• Lancet; HTLV-I associated myelopathy, a new clinical entity; M Osame, K Usuku, S Izumo, N Ijichi, H Amitani, A Igata, M Matsumoto, M Tara; 1; 1986; 1031-1032; 10.1016/S0140-6736(86)91298-5; citation_id=CR3
• Lancet; Antibodies to human T-lymphotropic virus type-I in patients with tropical spastic paraparesis; A Gessain, F Barin, JC Vernant, O Gout, L Maurs, A Calender, G de The; 2; 1985; 407-410; 10.1016/S0140-6736(85)92734-5; citation_id=CR4
• Neuropathology; HTLV-I-associated myelopathy; S Izumo, F Umehara, M Osame; 20; Suppl; 2000; S65-S68; 10.1046/j.1440-1789.2000.00320.x; citation_id=CR5

Terms in the title (14)： ウイルス ,  トランス活性化因子 ,  Tax ,  上方制御 ,  CCケモカイン ,  配位子 ,  CCL ,  ミノサイクリン ,  ダウンレギュレーション ,  HTLV-1関連脊髄症 ,  熱帯 ,  痙性対麻痺 ,  長期治療 ,  意味