Art

J-GLOBAL ID：201802232018623801   Reference number：18A0359542

Whole exome sequencing to identify genetic markers for trastuzumab-induced cardiotoxicity

トラスツズマブ誘発心毒性の遺伝的マーカーを同定する全エキソーム配列決定

Author (13)： Udagawa Chihiro (Division of Genetics, National Cancer Center Research Institute, Tokyo, Japan) ,  Udagawa Chihiro (Pharmacogenomics Group, Project for Development of Liquid Biopsy Diagnosis, Cancer Precision Medicine Center, Japanese Foundation for Cancer Research, Tokyo, Japan) ,  Nakamura Hiromi (Division of Cancer Genomics, National Cancer Center Research Institute, Tokyo, Japan) ,  Ohnishi Hiroshi (Division of Genetics, National Cancer Center Research Institute, Tokyo, Japan) ,  Ohnishi Hiroshi (Pharmacogenomics Group, Project for Development of Liquid Biopsy Diagnosis, Cancer Precision Medicine Center, Japanese Foundation for Cancer Research, Tokyo, Japan) ,  Tamura Kenji (Department of Breast and Medical Oncology, National Cancer Center Hospital, Tokyo, Japan) ,  Shimoi Tatsunori (Department of Breast and Medical Oncology, National Cancer Center Hospital, Tokyo, Japan) ,  Yoshida Masayuki (Department of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo, Japan) ,  Yoshida Teruhiko (Fundamental Innovative Oncology Core, National Cancer Center Research Institute, Tokyo, Japan) ,  Totoki Yasushi (Division of Cancer Genomics, National Cancer Center Research Institute, Tokyo, Japan) ,  Shibata Tatsuhiro (Division of Cancer Genomics, National Cancer Center Research Institute, Tokyo, Japan) ,  Zembutsu Hitoshi (Division of Genetics, National Cancer Center Research Institute, Tokyo, Japan) ,  Zembutsu Hitoshi (Pharmacogenomics Group, Project for Development of Liquid Biopsy Diagnosis, Cancer Precision Medicine Center, Japanese Foundation for Cancer Research, Tokyo, Japan)
Material： Cancer Science (Web)  (Cancer Sci (Web))
Volume： 109  Issue： 2  Page： 446-452  Publication year： 2018 
JST Material Number： U0505A  ISSN： 1349-7006  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： *monoclonal antibody ,...
Semi thesaurus term： *Trastuzumab ,...

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Author keywords (5)： cardiotoxicity ,  HER2 ,  pharmacogenomics ,  trastuzumab ,  whole exome sequencing

JST classification (2)： Clinical application of antitumor(=antineoplastic)drugs  (GW16020L) ,  Drug therapy(=pharmacotherapy)for tumors  (GE03032C)

Reference (52)：

• Hudis CA. Trastuzumab-mechanism of action and use in clinical practice. N Engl J Med. 2007;357:39-51.
• Cooke T, Reeves J, Lanigan A, Stanton P. HER2 as a prognostic and predictive marker for breast cancer. Ann Oncol. 2001;12(suppl 1):S23-S28.
• Cho HS, Mason K, Ramyar KX, et al. Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab. Nature. 2003;421:756-760.
• Hsieh AC, Moasser MM. Targeting HER proteins in cancer therapy and the role of the non-target HER3. Br J Cancer. 2007;97:453-457.
• Dankort D, Maslikowski B, Warner N, et al. Grb2 and Shc adapter proteins play distinct roles in Neu (ErbB-2)-induced mammary tumorigenesis: implications for human breast cancer. Mol Cell Biol. 2001;21:1540-1551.

Terms in the title (6)： トラスツズマブ ,  誘発 ,  心毒性 ,  遺伝的マーカー ,  同定 ,  全エキソーム配列決定