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J-GLOBAL ID：201802233673373216   Reference number：18A2242432

The performance of an in vitro skin sensitisation test, IL-8 Luc assay (OECD442E), and the integrated approach with direct peptide reactive assay (DPRA)

in vitro皮膚感作試験,IL-8 LUCアッセイ(OECD44E),直接ペプチド反応性アッセイ(DPRA)との統合アプローチの成績

Author (12)： Kimura Yutaka (Department of Dermatology, Tohoku University Graduate School of Medicine) ,  Watanabe Mika (Hatano Research Institute, Food and Drug Safety Center) ,  Suzuki Noriyuki (Environmental Health Science Laboratory, Sumitomo Chemical Co., Ltd.) ,  Iwaki Tomoko (Health Research Institute, Advanced Industrial Science and technology (AIST)) ,  Yamakage Kohji (Hatano Research Institute, Food and Drug Safety Center) ,  Saito Koichi (Environmental Health Science Laboratory, Sumitomo Chemical Co., Ltd.) ,  Nakajima Yoshihiro (Health Research Institute, Advanced Industrial Science and technology (AIST)) ,  Fujimura Chizu (Department of Dermatology, Tohoku University Graduate School of Medicine) ,  Ohmiya Yoshihiro (Biomedical Research Institute, Advanced Industrial Science and Technology (AIST)) ,  Omori Takashi (Division of Biostatistics, Department of Social/Community Medicine and Health Science, Kobe University School of Medicine) ,  Kojima Hajime (Japanese Center for the Validation of Alternative Methods) ,  Aiba Setsuya (Department of Dermatology, Tohoku University Graduate School of Medicine)
Material： Journal of Toxicological Sciences  (日本毒性学会学術年会プログラム・要旨集)
Volume： 43  Issue： 12  Page： 741-749(J-STAGE)  Publication year： 2018 
JST Material Number： Z0265B  ISSN： 0388-1350  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： sensitization (immunology) ,...
Semi thesaurus term： *immunoassay ,...

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Author keywords (5)： Contact dermatitis ,  Sensitisation test ,  Luciferase assay ,  Alternative method ,  Skin sensitisation

JST classification (2)： Dermatlogic diagnosis  (GF02000J) ,  Bioassay  (EA03060N)

Substance index (1)： Dimethyl sulfoxide

Reference (17)：

• Adler, S., Basketter, D., Creton, S., Pelkonen, O., van Benthem, J., et al. (2011): Alternative (non-animal) methods for cosmetics testing: current status and future prospects-2010. Arch. Toxicol., 85, 367-485.
• Gerberick, G.F., Ryan, C.A., Kern, P.S., Schlatter, H., Dearman, R.J., Kimber, I., Patlewicz, G.Y. and Basketter, D.A. (2005): Compilation of historical local lymph node data for evaluation of skin sensitization alternative methods. Dermatitis, 16, 157-202.
• Gerberick, G.F., Vassallo, J.D., Bailey, R.E., Chaney, J.G., Morrall, S.W. and Lepoittevin, J.P. (2004): Development of a peptide reactivity assay for screening contact allergens. Toxicol. Sci., 81, 332-343.
• Kimura, Y., Fujimura, C., Ito, Y., Takahashi, T., Nakajima, Y., Ohmiya, Y. and Aiba, S. (2015): Optimization of the IL-8 Luc assay as an in vitro test for skin sensitization. Toxicol. In Vitro, 29, 1816-1830.
• Kimura, Y., Fujimura, C., Ito, Y., Takahashi, T., Terui, H. and Aiba, S. (2018): Profiling the immunotoxicity of chemicals based on in vitro evaluation by a combination of the Multi-ImmunoTox assay and the IL-8 Luc assay. Arch. Toxicol., 92, 2043-2054.

Terms in the title (8)： 皮膚感作 ,  試験 ,  IL ,  アッセイ ,  ペプチド ,  反応性 ,  統合 ,  成績