Art

J-GLOBAL ID：201802239077086123   Reference number：18A0974631

Cytotoxicity of replication-competent adenoviruses powered by an exogenous regulatory region is not linearly correlated with the viral infectivity/gene expression or with the E1A-activating ability but is associated with the p53 genotypes

外因性調節領域により駆動される複製能のあるアデノウイルスの細胞毒性はウイルス感染性/遺伝子発現またはE1A活性化能と相関しないがp53遺伝子型と関連する【JST・京大機械翻訳】

Author (16)： Yamauchi Suguru (Division of Pathology and Cell Therapy, Chiba Cancer Center Research Institute, Chiba, Japan) ,  Yamauchi Suguru (Department of Molecular Biology and Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan) ,  Zhong Boya (Division of Pathology and Cell Therapy, Chiba Cancer Center Research Institute, Chiba, Japan) ,  Zhong Boya (Department of Molecular Biology and Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan) ,  Kawamura Kiyoko (Division of Pathology and Cell Therapy, Chiba Cancer Center Research Institute, Chiba, Japan) ,  Yang Shan (Division of Pathology and Cell Therapy, Chiba Cancer Center Research Institute, Chiba, Japan) ,  Yang Shan (Department of Molecular Biology and Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan) ,  Kubo Shuji (Department of Genetics, Hyogo College of Medicine, Nishinomiya, Japan) ,  Shingyoji Masato (Division of Respirology, Chiba Cancer Center, Chiba, Japan) ,  Sekine Ikuo (Department of Medical Oncology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan) ,  Tada Yuji (Department of Respirology, Graduate School of Medicine, Chiba University, Chiba, Japan) ,  Tatsumi Koichiro (Department of Respirology, Graduate School of Medicine, Chiba University, Chiba, Japan) ,  Shimada Hideaki (Department of Surgery, School of Medicine, Toho University, Tokyo, Japan) ,  Hiroshima Kenzo (Department of Pathology, Tokyo Women’s Medical University Yachiyo Medical Center, Yachiyo, Japan) ,  Tagawa Masatoshi (Division of Pathology and Cell Therapy, Chiba Cancer Center Research Institute, Chiba, Japan) ,  Tagawa Masatoshi (Department of Molecular Biology and Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan)
Material： BMC Cancer (Web)
Volume： 17  Issue： 1  Page： 622  Publication year： 2017 
JST Material Number： U7305A  ISSN： 1471-2407  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Abstract/Point： Background Replication-compete...

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Thesaurus term： human ,  flow cytometry ,  *gene expression ,  *cytotoxicity ,  biomarker ,  *Adenoviridae ,  tumor cell ,  vector (genetics) ,  *p53 gene ,  esophageal tumor ,  sensitivity ,  *viral infection ,  transcriptional activity ,  Ad5 ,  *molecular genetic phenomenon ,  *microorganism ,  *animal virus
Semi thesaurus term： *感染性 , 【Automatic Indexing@JST】

Author keywords (5)： Replication-competent adenovirus ,  Infectivity ,  Transcriptional activity ,  p53 genotype ,  Biomarker

JST classification (3)： Biochemical analytical methods  (EA03030G) ,  Cell physiology in general  (EF02010S) ,  Gene manipulation  (EC02050B)

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Terms in the title (11)： 調節領域 ,  複製 ,  アデノウイルス ,  細胞毒性 ,  ウイルス ,  感染性 ,  遺伝子発現 ,  E1A ,  活性化 ,  相関 ,  p53遺伝子