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J-GLOBAL ID：201802239177920344   Reference number：18A0061591

Supplemented Chondroitin Sulfate and Hyaluronic Acid Suppress Mineralization of the Chondrogenic Cell Line, ATDC5, via Direct Inhibition of Alkaline Phosphatase

コンドロイチン硫酸とヒアルロン酸の補充はアルカリ性ホスファターゼの直接阻害を介して軟骨形成細胞株,ATDC5の石灰化を抑制する

Author (7)： Kudo Toshiya (Department of Pharmaceutical Sciences, Josai University) ,  Nakatani Sachie (Department of Pharmaceutical Sciences, Josai University) ,  Kakizaki Misato (Department of Pharmaceutical Sciences, Josai University) ,  Arai Ai (Department of Pharmaceutical Sciences, Josai University) ,  Ishida Keisuke (Department of Pharmaceutical Sciences, Josai University) ,  Wada Masahiro (Department of Pharmaceutical Sciences, Josai University) ,  Kobata Kenji (Department of Pharmaceutical Sciences, Josai University)
Material： Biological and Pharmaceutical Bulletin  (Biological & Pharmaceutical Bulletin)
Volume： 40  Issue： 12  Page： 2075-2080(J-STAGE)  Publication year： 2017 
JST Material Number： S0989A  ISSN： 0918-6158  CODEN： BPBLEO  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *chondroitin sulfate ,...
Semi thesaurus term： chondroitinase ABC ,...

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Author keywords (8)： chondroitin sulfate ,  chondrocyte ,  alkaline phosphatase ,  mineralization ,  chondroitin sulfate ,  chondrocyte ,  alkaline phosphatase ,  mineralization

JST classification (1)： Basic medicine on musculoskeletal system  (GG01020B)

Reference (40)：

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• 2) Watanabe H, Yamada Y, Kimata K. Roles of aggrecan, a large chondroitin sulfate proteoglycan, in cartilage structure and function. J. Biochem., 124, 687-693 (1998).
• 3) Mackie EJ, Ahmed YA, Tatarczuch L, Chen KS, Mirams M. Endochondral ossification: how cartilage is converted into bone in the developing skeleton. Int. J. Biochem. Cell Biol., 40, 46-62 (2008).
• 4) Adams CS, Shapiro IM. The fate of the terminally differentiated chondrocyte: evidence for microenvironmental regulation of chondrocyte apoptosis. Crit. Rev. Oral Biol. Med., 13, 465-473 (2002).
• 5) Drissi H, Zuscik M, Rosier R, O’Keefe R. Transcriptional regulation of chondrocyte maturation: potential involvement of transcription factors in OA pathogenesis. Mol. Aspects Med., 26, 169-179 (2005).

Terms in the title (8)： コンドロイチン硫酸 ,  ヒアルロン酸 ,  補充 ,  アルカリ性ホスファターゼ ,  阻害 ,  軟骨形成 ,  細胞株 ,  石灰化