Art

J-GLOBAL ID：201802241606295267   Reference number：18A0420666

SIRT7 is an important regulator of cartilage homeostasis and osteoarthritis development

SIRT7は軟骨ホメオスタシスや変形性関節症発症の重要な調節因子である【Powered by NICT】

Author (12)： Korogi Wataru (Department of Medical Biochemistry, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan) ,  Korogi Wataru (Department of Orthopaedic Surgery, Faculty of Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan) ,  Yoshizawa Tatsuya (Department of Medical Biochemistry, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan) ,  Karim Md. Fazlul (Department of Medical Biochemistry, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan) ,  Tanoue Hironori (Department of Molecular Genetics, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan) ,  Yugami Masaki (Department of Molecular Genetics, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan) ,  Sobuz Shihab U. (Department of Medical Biochemistry, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan) ,  Hinoi Eiichi (Laboratory of Molecular Pharmacology, Division of Pharmaceutical Sciences, Kanazawa University Graduate School of Natural Science and Technology, Kanazawa, 920-1192, Japan) ,  Sato Yoshifumi (Department of Medical Biochemistry, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan) ,  Oike Yuichi (Department of Molecular Genetics, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan) ,  Mizuta Hiroshi (Department of Orthopaedic Surgery, Faculty of Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan) ,  Yamagata Kazuya (Department of Medical Biochemistry, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan)
Material： Biochemical and Biophysical Research Communications  (BBRC)
Volume： 496  Issue： 3  Page： 891-897  Publication year： 2018 
JST Material Number： B0118A  ISSN： 0006-291X  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Sirtuins (SIRT1-7) are NAD<sup...

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Thesaurus term： Extracellular Matrix ,  chondrocyte ,  knockout mouse ,  *osteoarthrosis ,  *Cartilage ,  transcription factor ,  enzyme activity ,  *homeostasis ,  biological activity ,  cartilage disease ,  mRNA expression ,  Chondrogenesis ,  deacetylase ,  Sirtuins ,  *controlling element ,  matrix (base) ,  laboratory animal ,  Mus musculus

Author keywords (6)： Osteoarthritis ,  Chondrocyte ,  Sirtuin ,  Deacylase ,  SIRT7 ,  SOX9

JST classification (2)： Skeletal system  (EJ10030R) ,  Gene expression  (EC02040Q)

Terms in the title (6)： Sirt7 ,  軟骨 ,  ホメオスタシス ,  変形性関節症 ,  発症 ,  調節因子