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J-GLOBAL ID：201802241980475025   Reference number：18A0532946

Lysine-containing cationic liposomes activate the NLRP3 inflammasome: Effect of a spacer between the head group and the hydrophobic moieties of the lipids

リジン含有カチオン性リポソームはNLRP3インフラマソームを活性化する:頭基の間のスペーサと脂質の疎水性部分の影響【Powered by NICT】

Author (7)： Li Tianshu (Research Organization for Nano & Life Innovation, Waseda University, Tokyo, Japan) ,  He Jieyan (Department of Life Science and Medical Bioscience, Graduate School of Advanced Science and Engineering, Waseda University, Tokyo, Japan) ,  Horvath Gabor (Institute of Innate Immunity, Biomedical Center, University Hospitals, University of Bonn, Bonn, Germany) ,  Prochnicki Tomasz (Institute of Innate Immunity, Biomedical Center, University Hospitals, University of Bonn, Bonn, Germany) ,  Latz Eicke (Institute of Innate Immunity, Biomedical Center, University Hospitals, University of Bonn, Bonn, Germany) ,  Takeoka Shinji (Research Organization for Nano & Life Innovation, Waseda University, Tokyo, Japan) ,  Takeoka Shinji (Department of Life Science and Medical Bioscience, Graduate School of Advanced Science and Engineering, Waseda University, Tokyo, Japan)
Material： Nanomedicine: Nanotechnology, Biology, and Medicine
Volume： 14  Issue： 2  Page： 279-288  Publication year： 2018 
JST Material Number： W3138A  ISSN： 1549-9634  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Cationic lipids containing lys...

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Thesaurus term： internalization ,  lysosome ,  *liposome ,  *lipid ,  zeta-potential ,  cytotoxicity ,  *hydrophobic ,  *spacer ,  interleukin 1 ,  natural immunity ,  nano particle ,  amino acid ,  aliphatic amine ,  aliphatic carboxylic acid ,  primary amine
Semi thesaurus term： *インフラマソーム ,  *NOD様受容体蛋白質3 ,  *正電荷脂質包埋型リポソーム , 【Automatic Indexing@JST】

Author keywords (5)： Lysine ,  Cationic liposomes ,  NLRP3 inflammasome activation ,  Il-1β ,  Lysosome rupture

JST classification (3)： Immunological reaction in general  (ED03010T) ,  Basic research of pharmacology of crude drugs  (GX06020J) ,  Cell physiology in general  (EF02010S)

Substance index (1)： Lysine

Terms in the title (8)： リジン ,  カチオン性リポソーム ,  NLRP3インフラマソーム ,  活性化 ,  頭 ,  スペーサ ,  脂質 ,  疎水性