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J-GLOBAL ID：201802242199800599   Reference number：18A1061729

Determining Transgene Expression Characteristics Using a Suction Device with Multiple Hole Adjusting a Left Lateral Lobe of the Mouse Liver

マウス肝臓の左外側葉を調整する多孔を持つ吸引装置を用いる導入遺伝子発現特性の決定

Author (8)： Haraguchi Ayana (Graduate School of Biomedical Sciences, Nagasaki University) ,  Fuchigami Yuki (Graduate School of Biomedical Sciences, Nagasaki University) ,  Kawaguchi Maho (Graduate School of Biomedical Sciences, Nagasaki University) ,  Fumoto Shintaro (Graduate School of Biomedical Sciences, Nagasaki University) ,  Ohyama Kaname (Graduate School of Biomedical Sciences, Nagasaki University) ,  Shimizu Kazunori (Department of Biomolecular Engineering, Graduate School of Engineering, Nagoya University) ,  Hagimori Masayori (Graduate School of Biomedical Sciences, Nagasaki University) ,  Kawakami Shigeru (Graduate School of Biomedical Sciences, Nagasaki University)
Material： Biological and Pharmaceutical Bulletin (Web)
Volume： 41  Issue： 6  Page： 944-950(J-STAGE)  Publication year： 2018 
JST Material Number： U1402A  ISSN： 1347-5215  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *liver ,...
Semi thesaurus term： AP-1 ,...

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Author keywords (8)： gene delivery ,  naked plasmid DNA ,  liver ,  hepatocyte ,  gene delivery ,  naked plasmid DNA ,  liver ,  hepatocyte

JST classification (3)： Research methods in genetics  (EC01020N) ,  Basic medicine on digestive system  (GH01020E) ,  Medical instruments and apparatuses  (GA05020L)

Reference (27)：

• 1) Fumoto S, Kawakami S. Combination of nanoparticles with physical stimuli toward cancer therapy. Biol. Pharm. Bull., 37, 212-216 (2014).
• 2) Liu F, Song YK, Liu D. Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA. Gene Ther., 6, 1258-1266 (1999).
• 3) Crespo A, Peydró A, Dasí F, Benet M, Calvete JJ, Revert F, Aliño SF. Hydrodynamic liver gene transfer mechanism involves transient sinusoidal blood stasis and massive hepatocyte endocytic vesicles. Gene Ther., 12, 927-935 (2005).
• 4) Umemoto Y, Kawakami S, Otani Y, Higuchi Y, Yamashita F, Hashida M. Evaluation of long-term gene expression in mouse liver using phiC31 integrase and hydrodynamic injection. Biol. Pharm. Bull., 35, 1182-1186 (2012).
• 5) Kamimura K, Suda T, Xu W, Zhang G, Liu D. Image-guided, lobe-specific hydrodynamic gene delivery to swine liver. Mol. Ther., 17, 491-499 (2009).

Terms in the title (5)： マウス ,  肝臓 ,  多孔 ,  吸引装置 ,  導入遺伝子発現