Art

J-GLOBAL ID：201802246613468099   Reference number：18A1922286

Inhibitory effect of the gut microbial linoleic acid metabolites, 10-oxo-trans-11-octadecenoic acid and 10-hydroxy-cis-12-octadecenoic acid, on BV-2 microglial cell activation

BV-2ミクログリア細胞活性化に及ぼす腸内微生物リノール酸代謝物,10-オキソ-trans-11-オクタデセン酸および10-ヒドロキシ-cis-12-オクタデセン酸の阻害効果

Author (9)： Ikeguchi Shiori (Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Shimoadachi-cho, Sakyo-ku, Kyoto 606-8501, Japan) ,  Izumi Yasuhiko (Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Shimoadachi-cho, Sakyo-ku, Kyoto 606-8501, Japan) ,  Izumi Yasuhiko (Department of Pharmacology, Kobe Pharmaceutical University, 4-19-1 Motoyamakita-machi, Higashinada-ku, Kobe, 658-8558, Japan) ,  Kitamura Nahoko (Department of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kitashirakawaoiwake-cho, Sakyo-ku, Kyoto 606-8502, Japan) ,  Kishino Shigenobu (Department of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kitashirakawaoiwake-cho, Sakyo-ku, Kyoto 606-8502, Japan) ,  Ogawa Jun (Department of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kitashirakawaoiwake-cho, Sakyo-ku, Kyoto 606-8502, Japan) ,  Akaike Akinori (Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Shimoadachi-cho, Sakyo-ku, Kyoto 606-8501, Japan) ,  Kume Toshiaki (Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Shimoadachi-cho, Sakyo-ku, Kyoto 606-8501, Japan) ,  Kume Toshiaki (Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama-shi, Toyama 930-0194, Japan)
Material： Journal of Pharmacological Sciences (Web)  (J Pharmacol Sci (Web))
Volume： 138  Issue： 1  Page： 9-15  Publication year： 2018 
JST Material Number： U0667A  ISSN： 1347-8613  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： cultured cell ,...
Semi thesaurus term： BV-2 cell ,...

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Author keywords (5)： Microglia ,  Polyunsaturated fatty acids ,  Gut bacterium ,  MAPKs ,  Inflammation

JST classification (2)： Basic neurology  (GN01020W) ,  Biological function  (EB05020M)

Substance index (3)： (Z)-10-Hydroxy-12-octadecenoic acid ,  (E)-10-Oxo-11-octadecenoic acid ,  Linolic acid

Terms in the title (8)： ミクログリア細胞 ,  活性化 ,  腸内微生物 ,  リノール酸 ,  代謝物 ,  11-オクタデセン酸 ,  cis-12-オクタデセン酸 ,  阻害効果