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J-GLOBAL ID：201802247763744087   Reference number：18A0379896

Mechanisms for Improved Hygroscopicity of L-Arginine Valproate Revealed by X-Ray Single Crystal Structure Analysis

X線単結晶構造解析によって明らかにされたL-アルギニンバルプロ酸の改善された吸湿性の機構【Powered by NICT】

Author (8)： Ito Masataka (Faculty of Pharmaceutical Sciences, Toho University, 2-2-1 Miyama, Funabashi, Chiba 274-8510, Japan) ,  Nambu Kaori (Faculty of Pharmaceutical Sciences, Toho University, 2-2-1 Miyama, Funabashi, Chiba 274-8510, Japan) ,  Sakon Aya (Department of Chemistry and Materials Science, Tokyo Institute of Technology, 2-12-1 Ookayama, Meguro-ku, Tokyo 152-8551, Japan) ,  Uekusa Hidehiro (Department of Chemistry and Materials Science, Tokyo Institute of Technology, 2-12-1 Ookayama, Meguro-ku, Tokyo 152-8551, Japan) ,  Yonemochi Etsuo (School of Pharmacy and Pharmaceutical Sciences, Hoshi University, 2-4-41 Ebara, Shinagawa, Tokyo 142-8501, Japan) ,  Noguchi Shuji (Faculty of Pharmaceutical Sciences, Toho University, 2-2-1 Miyama, Funabashi, Chiba 274-8510, Japan) ,  Terada Katsuhide (Faculty of Pharmaceutical Sciences, Toho University, 2-2-1 Miyama, Funabashi, Chiba 274-8510, Japan) ,  Terada Katsuhide (Faculty of Pharmacy, Takasaki University of Health and Welfare, 60 Nakaorui-machi, Takasaki, Gunma 370-0033, Japan)
Material： Journal of Pharmaceutical Sciences  (J Pharm Sci)
Volume： 106  Issue： 3  Page： 859-865  Publication year： 2017 
JST Material Number： C0260B  ISSN： 0022-3549  CODEN： JPMSAE  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Valproic acid is widely used a...

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Thesaurus term： *single crystal ,  liquid phase ,  water molecule ,  sorption ,  solid phase ,  *crystal structure ,  relative humidity ,  Adsorption ,  steric conformation ,  screening (inspection) ,  characterization ,  *hygroscopicity ,  morphology ,  phase (thermodynamics) ,  fatty acid ,  carboxylate (salt)

Author keywords (9)： crystallography ,  X-ray powder diffractometry ,  crystal structure ,  deliquescence ,  hygroscopicity ,  physical characterization ,  salts/salt selection ,  crystal engineering ,  formulation

JST classification (2)： Basic biopharmacy  (GY01021U) ,  Pharmaceutical preparations in general  (GY02010Z)

Substance index (2)： Sodium valproate ,  Valproic acid

Terms in the title (5)： X線 ,  単結晶構造解析 ,  L-アルギニン ,  バルプロ酸 ,  吸湿性