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J-GLOBAL ID：201802247860708683   Reference number：18A1979372

リゾリン脂質メディエーター研究の最前線 2型スフィンゴシン1-リン酸受容体S1P2の病態生理機能

Author (1)： TAKUWA YO (金沢大 医薬保健研究域 医学系 血管分子生理学分野)
Material： 生化学
Volume： 90  Issue： 5  Page： 565-573  Publication year： Oct. 25, 2018 
JST Material Number： G0184A  ISSN： 0037-1017  CODEN： SEIKAQ  Document type： Article
Article type： 文献レビュー  Country of issue： Japan (JPN)  Language： JAPANESE (JA)

Thesaurus term： *signal transduction receptor ,...
Semi thesaurus term： *cellular signal transduction ,...

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JST classification (4)： Biological function  (EB05020M) ,  Cell physiology in general  (EF02010S) ,  Receptors on cell membrane  (EF04030C) ,  Biosubstance in general  (EB02010G)

Substance index (2)： Sphingosine-1-phosphate ,  Sphingosine

Reference (53)：

• Zhang, H., Desai, N.N., Olivera, A., Seki, T., Brooker, G., & Spiegel, S. (1991) Sphingosine-1-phosphate, a novel lipid, involved in cellular proliferation. J. Cell Biol., 114, 155-167.
• Sadahira, Y., Ruan, F., Hakomori, S., & Igarashi, Y. (1992) Sphingosine 1-phosphate, a specific endogenous signaling molecule controlling cell motility and tumor cell invasiveness. Proc. Natl. Acad. Sci. USA, 89, 9686-p690.
• Yatomi, Y., Igarashi, Y., Yang, L., Hisano, N., Qi, R., Asazuma, N., Satoh, K., Ozaki, Y., & Kume, S. (1997) Sphingosine 1-phosphate, a bioactive sphingolipid abundantly stored in platelets, is a normal constituent of human plasma and serum. J. Biochem., 121, 969-973.
• Lee, M.J., Van Brocklyn, J.R., Thangada, S., Liu, C.H., Hand, A.R., Menzeleev, R., Spiegel, S., & Hla, T. (1998) Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor EDG-1. Science, 279, 1552-1555.
• Okamoto, H., Takuwa, N., Gonda, K., Okazaki, H., Chang, K., Yatomi, Y., Shigematsu, H., & Takuwa, Y. (1998) EDG1 is a functional sphingosine-1-phosphate receptor that is linked via a Gi/o to multiple signaling pathways, including phospholipase C activation, Ca²⁺ mobilization, Ras-mitogen-activated protein kinase activation, and adenylate cyclase inhibition. J. Biol. Chem., 273, 27104-27110.

Terms in the title (4)： 脂質メディエーター ,  研究 ,  スフィンゴシン1-リン酸受容体 ,  病態生理