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J-GLOBAL ID：201802249185323535   Reference number：18A0275464

Prostaglandin E₁ reduces the keratinocyte toxicity of sorafenib by maintaining signal transducer and activator of transcription 3 (STAT3) activity and enhancing the cAMP response element binding protein (CREB) activity

プロスタグランジンE_1は転写3(STAT3)活性のシグナルトランスデューサーと活性化剤の維持とcAMP応答要素結合蛋白質(CREB)活性を増強することによりソラフェニブのケラチン細胞毒性を低下させる【Powered by NICT】

Author (14)： Shichiri Hiroaki (Division of Pharmaceutics, Department of Internal Related, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan) ,  Yamamoto Kazuhiro (Department of Pharmacy, Kobe University Hospital, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan) ,  Tokura Maya (Educational Center for Clinical Pharmacy, Kobe Pharmaceutical University, 4-19-1, Motoyamakitamachi, Higashinada-ku, Kobe-shi, Hyogo, 658-8558, Japan) ,  Ishida Takahiro (R&D Department, Momotani Juntenkan LTD, 1-4-1, Uemachi, Chuo-ku, Osaka, 540-0005, Japan) ,  Uda Atsushi (Department of Pharmacy, Kobe University Hospital, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan) ,  Bito Toshinori (Division of Dermatology, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan) ,  Nishigori Chikako (Division of Dermatology, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan) ,  Nakagawa Tsutomu (Division of Pharmaceutics, Department of Internal Related, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan) ,  Nakagawa Tsutomu (Department of Pharmacy, Kobe University Hospital, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan) ,  Hirano Takeshi (Department of Pharmacy, Kobe University Hospital, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan) ,  Yano Ikuko (Division of Pharmaceutics, Department of Internal Related, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan) ,  Yano Ikuko (Department of Pharmacy, Kobe University Hospital, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan) ,  Hirai Midori (Division of Pharmaceutics, Department of Internal Related, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan) ,  Hirai Midori (Department of Pharmacy, Kobe University Hospital, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan)
Material： Biochemical and Biophysical Research Communications  (BBRC)
Volume： 485  Issue： 2  Page： 227-233  Publication year： 2017 
JST Material Number： B0118A  ISSN： 0006-291X  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Hand-foot skin reaction (HFSR)...

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Thesaurus term： *CRE binding protein ,  myeloid cell ,  phosphorylation ,  leukemia ,  human(primates) ,  *toxicity ,  angiogenesis ,  *keratinocyte ,  cell proliferation ,  pathogenesis ,  molecular targeting drug ,  adenine nucleotide ,  ribonucleotide ,  cyclic nucleotide
Semi thesaurus term： 細胞生存 ,  阻害剤 ,  *STAT3転写因子 , 【Automatic Indexing@JST】

Author keywords (5)： Sorafenib ,  Prostaglandin E₁ ,  STAT3 ,  Keratinocyte ,  Hand-foot skin reaction

JST classification (3)： Function of cell components  (EF03060C) ,  Chemistry,biochemistry and pathology of tumors(=neoplasms)  (GE02030N) ,  Cell physiology in general  (EF02010S)

Substance index (2)： Sorafenib ,  cAMP

Terms in the title (14)： 転写 ,  STAT3 ,  活性 ,  シグナル ,  トランスデューサー ,  活性化剤 ,  cAMP ,  応答要素 ,  結合蛋白質 ,  CREB ,  増強 ,  ソラフェニブ ,  ケラチン ,  細胞毒性