Art

J-GLOBAL ID：201802251192168884   Reference number：18A1689420

Overcoming Resistance to Dual Innate Immune and MEK Inhibition Downstream of KRAS

KRASの下流における二重自然免疫およびMEK阻害に対する抵抗性の克服【JST・京大機械翻訳】

Author (35)： Kitajima Shunsuke (Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA) ,  Asahina Hajime (Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA) ,  Asahina Hajime (First Department of Medicine, Hokkaido University School of Medicine, Sapporo 060-8638, Japan) ,  Chen Ting (Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA) ,  Chen Ting (Perlmutter Cancer Center, New York University Langone Medical Center, New York, NY 10016, USA) ,  Guo Sujuan (Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA) ,  Guo Sujuan (Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, MA 02215, USA) ,  Quiceno Laura Gutierrez (Perlmutter Cancer Center, New York University Langone Medical Center, New York, NY 10016, USA) ,  Cavanaugh Jillian D. (Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA) ,  Merlino Ashley A. (Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA) ,  Tange Shoichiro (Department of Human Genetics, Graduate School of Biomedical Science, Tokushima University, Tokushima 770-8503, Japan) ,  Terai Hideki (Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA) ,  Kim Jong Wook (Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA) ,  Kim Jong Wook (Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA) ,  Wang Xiaoen (Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA) ,  Wang Xiaoen (Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, MA 02215, USA) ,  Zhou Shan (Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA) ,  Zhou Shan (Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, MA 02215, USA) ,  Xu Man (Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA) ,  Xu Man (Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, MA 02215, USA) ,  Wang Stephen (Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA) ,  Wang Stephen (Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, MA 02215, USA) ,  Zhu Zehua (Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA) ,  Thai Tran C. (Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA) ,  Takahashi Chiaki (Division of Oncology and Molecular Biology, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa 920-1192, Japan) ,  Wang Yujin (Gilead Sciences, Foster City, CA 94404, USA) ,  Neve Richard (Gilead Sciences, Foster City, CA 94404, USA) ,  Stinson Susanna (Gilead Sciences, Foster City, CA 94404, USA) ,  Tamayo Pablo (Moores Cancer Center and School of Medicine, University of California San Diego, La Jolla, CA 92093, USA) ,  Watanabe Hideo (Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Kirschmeier Paul T. (Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA) ,  Kirschmeier Paul T. (Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, MA 02215, USA) ,  Wong Kwok-Kin (Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA) ,  Wong Kwok-Kin (Perlmutter Cancer Center, New York University Langone Medical Center, New York, NY 10016, USA) ,  Barbie David A. (Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA)
Material： Cancer Cell
Volume： 34  Issue： 3  Page： 439-452.e6  Publication year： 2018 
JST Material Number： W1844A  ISSN： 1535-6108  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Despite extensive efforts, onc...

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Thesaurus term： molecular target therapy ,  sensitivity ,  promoter(genetics) ,  *natural immunity ,  therapeutic planning ,  up-regulation ,  acetylation ,  cellular signal transduction ,  therapy
Semi thesaurus term： TP53 ,  阻害剤 ,  セクレトーム ,  LKB1 ,  TANK結合キナーゼ 1 ,  *K-Ras , 【Automatic Indexing@JST】

Author keywords (10)： non-small-cell lung cancer ,  KRAS ,  TP53 ,  STK11/LKB1 ,  IL-6 ,  innate immune signaling ,  YAP1 signaling ,  TBK1 inhibitor ,  MEK inhibitor ,  BET inhibitor

JST classification (4)： Cell physiology in general  (EF02010S) ,  Chemistry,biochemistry and pathology of tumors(=neoplasms)  (GE02030N) ,  Biological function  (EB03040U) ,  Carcinogenic mechanisms and factors  (GE02020C)

Terms in the title (6)： KRAS ,  下流 ,  自然免疫 ,  MEK ,  阻害 ,  抵抗性