Art

J-GLOBAL ID：201802252067223826   Reference number：18A0112193

Effects of high-fat diet and fructose-rich diet on obesity, dyslipidemia and hyperglycemia in the WBN/Kob-Lepr^fa rat, a new model of type 2 diabetes mellitus

WBN/コーブ-Leprfaラット,タイプ2糖尿病の新モデル,における肥満,異脂肪血症,および高血糖症におよぼす高脂肪食とフルクトースの豊富な食餌の影響

Author (8)： NAMEKAWA Junichi (Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Azabu University, Sagamihara, Kanagawa 252-5201, Japan) ,  TAKAGI Yoshiichi (Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Azabu University, Sagamihara, Kanagawa 252-5201, Japan) ,  WAKABAYASHI Kaoru (Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Azabu University, Sagamihara, Kanagawa 252-5201, Japan) ,  NAKAMURA Yuki (Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Azabu University, Sagamihara, Kanagawa 252-5201, Japan) ,  WATANABE Ayaka (Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Azabu University, Sagamihara, Kanagawa 252-5201, Japan) ,  NAGAKUBO Dai (Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Azabu University, Sagamihara, Kanagawa 252-5201, Japan) ,  SHIRAI Mitsuyuki (Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Azabu University, Sagamihara, Kanagawa 252-5201, Japan) ,  ASAI Fumitoshi (Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Azabu University, Sagamihara, Kanagawa 252-5201, Japan)
Material： Journal of Veterinary Medical Science (Web)
Volume： 79  Issue： 6  Page： 988-991(J-STAGE)  Publication year： 2017 
JST Material Number： U1094A  ISSN： 1347-7439  Document type： Article
Article type： 短報  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *rat ,...
Semi thesaurus term： *Dyslipidemias ,...

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Author keywords (5)： diet-induced obesity ,  fructose-rich diet ,  high-fat diet ,  type 2 diabetes ,  WBN/Kob-Lepr^fa rat

JST classification (4)： Laboratry organisms  (EA03070Y) ,  Special feeds  (FD07050O) ,  Animal diseases in general  (FE02010Q) ,  Metabolic diseases,nutritional diseases in general.  (GD05010J)

Substance index (1)： Fructose

Reference (21)：

• 1. Akimoto, T., Nakama, K., Katsuta, Y., Zhang, X. J., Ohsuga, M., Ishizaki, M., Sawai, N. and Ozawa, H. 2008. Characterization of a novel congenic strain of diabetic fatty (WBN/Kob-Lepr(fa)) rat. Biochem. Biophys. Res. Commun. 366: 556-562.
• 2. Anderson, P. J., Critchley, J. A., Chan, J. C., Cockram, C. S., Lee, Z. S., Thomas, G. N. and Tomlinson, B. 2001. Factor analysis of the metabolic syndrome: obesity vs insulin resistance as the central abnormality. Int. J. Obes. Relat. Metab. Disord. 25: 1782-1788.
• 3. Bandini, L. G., Vu, D., Must, A., Cyr, H., Goldberg, A. and Dietz, W. H. 1999. Comparison of high-calorie, low-nutrient-dense food consumption among obese and non-obese adolescents. Obes. Res. 7: 438-443.
• 4. Buettner, R., Schölmerich, J. and Bollheimer, L. C. 2007. High-fat diets: modeling the metabolic disorders of human obesity in rodents. Obesity (Silver Spring) 15: 798-808.
• 5. Catena, C., Giacchetti, G., Novello, M., Colussi, G., Cavarape, A. and Sechi, L. A. 2003. Cellular mechanisms of insulin resistance in rats with fructose-induced hypertension. Am. J. Hypertens. 16: 973-978.

Terms in the title (10)： ラット ,  タイプ ,  糖尿病 ,  モデル ,  肥満 ,  異脂肪血症 ,  高血糖症 ,  高脂肪食 ,  フルクトース ,  食餌