Art

J-GLOBAL ID：201802254029092529   Reference number：18A0469576

Region-specific deletions of the glutamate transporter GLT1 differentially affect seizure activity and neurodegeneration in mice

グルタミン酸輸送体GLT1の領域特異的欠失は,マウスにおける発作活性と神経変性に差別的に影響を及ぼす【Powered by NICT】

Author (10)： Sugimoto Junya (Laboratory of Molecular Neuroscience, Medical Research Institute (MRI), Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan) ,  Tanaka Moeko (Laboratory of Molecular Neuroscience, Medical Research Institute (MRI), Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan) ,  Sugiyama Kaori (Laboratory of Molecular Neuroscience, Medical Research Institute (MRI), Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan) ,  Ito Yukiko (Laboratory of Molecular Neuroscience, Medical Research Institute (MRI), Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan) ,  Aizawa Hidenori (Laboratory of Molecular Neuroscience, Medical Research Institute (MRI), Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan) ,  Soma Miho (Laboratory of Molecular Neuroscience, Medical Research Institute (MRI), Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan) ,  Shimizu Tomoko (Laboratory of Physiology, Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, 606-8507, Japan) ,  Mitani Akira (Laboratory of Physiology, Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, 606-8507, Japan) ,  Tanaka Kohichi (Laboratory of Molecular Neuroscience, Medical Research Institute (MRI), Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan) ,  Tanaka Kohichi (Center for Brain Integration Research (CBIR), TMDU, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan)
Material： GLIA
Volume： 66  Issue： 4  Page： 777-788  Publication year： 2018 
JST Material Number： W0157A  ISSN： 0894-1491  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： Glial glutamate transporter GL...

Register(free) or Log In to access     To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=18A0469576&from=J-GLOBAL&jstjournalNo=W0157A") }}

Thesaurus term： homeostasis ,  dysfunction ,  Eumetopias jubata ,  human ,  pathogenesis ,  Spinal Cord ,  Brain Stem ,  Phenotype ,  Cell Death ,  *seizure (disease) ,  convulsion ,  Epilepsy ,  knockout mouse ,  NMDA receptor ,  *glutamate transporter ,  laboratory animal ,  Mus musculus

Author keywords (6)： astrocyte ,  conditional knockout mice ,  infantile epilepsy ,  NMDA receptor ,  seizure-induced cell death ,  sudden unexpected death in epilepsy (SUDEP)

JST classification (2)： Central nervous system  (EJ12030F) ,  Transport of cell membrane  (EF04020R)

Terms in the title (8)： グルタミン酸輸送体 ,  GLT1 ,  欠失 ,  マウス ,  発作 ,  活性 ,  神経変性 ,  差別