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J-GLOBAL ID：201802255001267749   Reference number：18A0335280

Phosphorylated CIS suppresses the Epo or JAK2 V617F mutant-triggered cell proliferation through binding to EpoR

りん酸化されたCISはEpoRへの結合を介してEpoまたはJAK2V617F変異誘発細胞増殖を抑制する【Powered by NICT】

Author (7)： Funakoshi-Tago Megumi (Department of Hygienic Chemistry, Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo 105-8512, Japan) ,  Moriwaki Takuro (Department of Hygienic Chemistry, Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo 105-8512, Japan) ,  Ueda Fumihito (Department of Hygienic Chemistry, Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo 105-8512, Japan) ,  Tamura Hiroomi (Department of Hygienic Chemistry, Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo 105-8512, Japan) ,  Kasahara Tadashi (Department of Hygienic Chemistry, Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo 105-8512, Japan) ,  Kasahara Tadashi (Iternational University of Health and Welfare, Graduate School, 1-3-3 Minamiaoyama, Minato-ku, Tokyo, 107-0062, Japan) ,  Tago Kenji (Division of Structural Biochemistry, Department of Biochemistry, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi-ken 329-0498, Japan)
Material： Cellular Signalling  (Cell Signal)
Volume： 31  Page： 41-57  Publication year： 2017 
JST Material Number： T0667A  ISSN： 0898-6568  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： The JAK2 V617F mutant-mediated...

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Thesaurus term： RNA interference ,  nude mouse ,  carcinogenicity ,  Gene Silencing ,  tumorigenesis ,  interaction ,  Apoptosis ,  STAT transcription factor ,  *Cell Proliferation ,  antitumor action ,  *mutagenesis ,  *phosphorylation ,  *Janus Kinase 2 ,  SOCS ,  *Genetic Variation ,  Heredity
Semi thesaurus term： *variation(biology) , 【Automatic Indexing@JST】

Author keywords (5)： JAK2 ,  V617F mutation ,  Myeloproliferative neoplasms (MPNs) ,  CIS ,  SOCS1

JST classification (1)： Cell physiology in general  (EF02010S)

Terms in the title (6)： りん酸化 ,  CIS ,  EPO ,  JAK2V617F ,  変異誘発 ,  細胞増殖