Art

J-GLOBAL ID：201802255066689458   Reference number：18A1429360

Turbulence Activates Platelet Biogenesis to Enable Clinical Scale Ex Vivo Production

乱流は臨床スケールex vivo生産を可能にする血小板生合成を活性化する【JST・京大機械翻訳】

Author (31)： Ito Yukitaka (Department of Clinical Application, Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan) ,  Ito Yukitaka (Kyoto Development Center, Megakaryon Corporation, Kyoto, Japan) ,  Nakamura Sou (Department of Clinical Application, Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan) ,  Sugimoto Naoshi (Department of Clinical Application, Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan) ,  Shigemori Tomohiro (Kyoto Development Center, Megakaryon Corporation, Kyoto, Japan) ,  Kato Yoshikazu (Mixing Technology Laboratory, SATAKE Chemical Equipment Manufacturing Ltd., Saitama, Japan) ,  Ohno Mikiko (Department of Pharmacology, Shiga University of Medical Science, Otsu, Japan) ,  Sakuma Shinya (Department of Micro-Nano Systems Engineering, Nagoya University, Nagoya, Japan) ,  Ito Keitaro (Department of Micro-Nano Systems Engineering, Nagoya University, Nagoya, Japan) ,  Kumon Hiroki (Department of Micro-Nano Systems Engineering, Nagoya University, Nagoya, Japan) ,  Hirose Hidenori (Kyoto Development Center, Megakaryon Corporation, Kyoto, Japan) ,  Okamoto Haruki (Kyoto Development Center, Megakaryon Corporation, Kyoto, Japan) ,  Nogawa Masayuki (Center for Transfusion Medicine and Cell Therapy, Keio University School of Medicine, Tokyo, Japan) ,  Iwasaki Mio (Department of Life Science Frontiers, Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan) ,  Kihara Shunsuke (Department of Fundamental Cell Technology, Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan) ,  Fujio Kosuke (Department of Clinical Application, Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan) ,  Matsumoto Takuya (Department of Clinical Application, Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan) ,  Higashi Natsumi (Department of Clinical Application, Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan) ,  Hashimoto Kazuya (Department of Clinical Application, Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan) ,  Sawaguchi Akira (Department of Anatomy, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan) ,  Harimoto Ken-ichi (Department of Clinical Application, Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan) ,  Nakagawa Masato (Department of Life Science Frontiers, Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan) ,  Yamamoto Takuya (Department of Life Science Frontiers, Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan) ,  Yamamoto Takuya (AMED-CREST, AMED, Tokyo, Japan) ,  Handa Makoto (Center for Transfusion Medicine and Cell Therapy, Keio University School of Medicine, Tokyo, Japan) ,  Watanabe Naohide (Center for Transfusion Medicine and Cell Therapy, Keio University School of Medicine, Tokyo, Japan) ,  Nishi Eiichiro (Department of Pharmacology, Shiga University of Medical Science, Otsu, Japan) ,  Arai Fumihito (Department of Micro-Nano Systems Engineering, Nagoya University, Nagoya, Japan) ,  Nishimura Satoshi (Center for Molecular Medicine, Jichi Medical University, Tochigi, Japan) ,  Eto Koji (Department of Clinical Application, Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan) ,  Eto Koji (Department of Regenerative Medicine, Chiba University Graduate School of Medicine, Chiba, Japan)
Material： Cell (Cambridge, Mass.)  (Cell (Camb. Mass.))
Volume： 174  Issue： 3  Page： 636-648.e18  Publication year： 2018 
JST Material Number： A0707B  ISSN： 0092-8674  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： The ex vivo generation of plat...

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Thesaurus term： megakaryocyte ,  reaction mechanism ,  bioreactor ,  versatility ,  scale up ,  hemostasis ,  human(primates) ,  *turbulent flow ,  shearing stress ,  *thrombocyte ,  donor ,  blood transfusion ,  regenerative medicine ,  *biosynthesis ,  donor
Semi thesaurus term： *ex vivo実験 , 【Automatic Indexing@JST】

Author keywords (10)： platelet ,  megakaryocyte ,  iPSC ,  bioreactor ,  turbulence ,  shear stress ,  IGFBP2 ,  MIF ,  Nardilysin ,  regenerative medicine

JST classification (1)： Fibrinolysis and blood coagulation  (EJ03040S)

Terms in the title (6)： 乱流 ,  臨床 ,  スケール ,  血小板 ,  生合成 ,  活性化