Art

J-GLOBAL ID：201802255880199937   Reference number：18A1021356

Inhibitory effect of fasiglifam on hepatitis B virus infections through suppression of the sodium taurocholate cotransporting polypeptide

タウロコール酸ナトリウム共輸送ポリペプチドの抑制によるB型肝炎ウイルス感染に対するファシグリファムの阻害効果【JST・京大機械翻訳】

Author (9)： Nio Yasunori (Takeda Pharmaceutical Company Limited, Pharmaceutical Research Division, 26-1, Muraoka-Higashi 2-Chome, Fujisawa, Kanagawa, 251-8555, Japan) ,  Akahori Yuichi (Laboratory of Tumour Viruses, Institute for Frontier Life and Medical Sciences, Kyoto University, 53 Kawaharacho, Shogoin, Sakyoku, Kyoto 606-8507, Japan) ,  Akahori Yuichi (Grad. Sch. of Biostudies, Kyoto University, 53 Kawaharacho, Shogoin, Sakyoku, Kyoto 606-8507, Japan) ,  Okamura Hitomi (Laboratory of Tumour Viruses, Institute for Frontier Life and Medical Sciences, Kyoto University, 53 Kawaharacho, Shogoin, Sakyoku, Kyoto 606-8507, Japan) ,  Okamura Hitomi (Grad. Sch. of Biostudies, Kyoto University, 53 Kawaharacho, Shogoin, Sakyoku, Kyoto 606-8507, Japan) ,  Watashi Koichi (Department of Virology II, National Institute of Infectious Diseases, Tokyo 162-8640, Japan) ,  Wakita Takaji (Department of Virology II, National Institute of Infectious Diseases, Tokyo 162-8640, Japan) ,  Hijikata Makoto (Laboratory of Tumour Viruses, Institute for Frontier Life and Medical Sciences, Kyoto University, 53 Kawaharacho, Shogoin, Sakyoku, Kyoto 606-8507, Japan) ,  Hijikata Makoto (Grad. Sch. of Biostudies, Kyoto University, 53 Kawaharacho, Shogoin, Sakyoku, Kyoto 606-8507, Japan)
Material： Biochemical and Biophysical Research Communications  (BBRC)
Volume： 501  Issue： 3  Page： 820-825  Publication year： 2018 
JST Material Number： B0118A  ISSN： 0006-291X  Document type： Article
Article type： 短報  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Fasiglifam is a selective part...

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Thesaurus term： receptor ,  *polypeptide ,  HepG2 cell ,  genome ,  safety ,  *hepatitis B virus ,  *cotransport ,  pretreatment ,  human(primates) ,  hepatocyte ,  *infection ,  clinical trial ,  therapy
Semi thesaurus term： 過剰発現 , 【Automatic Indexing@JST】

Author keywords (6)： Hepatitis B virus ,  NTCP ,  Fasiglifam ,  Viral entry inhibitor ,  PXB mice ,  HepG2-hNTCP-C4 cells

JST classification (5)： Physiology and pathogenicity of virus infection  (EG04042Y) ,  Virus biochemistry  (EG04030F) ,  Cell physiology in general  (EF02010S) ,  Basic research of antiviral drugs  (GW17040O) ,  Function of cell components  (EF03060C)

Substance index (1)： Fasiglifam

Terms in the title (6)： タウロコール酸ナトリウム ,  共輸送 ,  ポリペプチド ,  B型肝炎ウイルス感染 ,  ファシグリファム ,  阻害効果