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J-GLOBAL ID：201802257671599149   Reference number：18A1780750

The trans isomer of Tau peptide is prone to aggregate, and the WW domain of Pin1 drastically decreases its aggregation

タウペプチドのトランス異性体は,Pin1の凝集とWwドメインが,その凝集を劇的に減少させる【JST・京大機械翻訳】

Author (11)： Ikura Teikichi (Medical Research Institute, Tokyo Medical and Dental University, Japan) ,  Tochio Naoya (Reseach Center for the Mathematics on Chromatin Live Dynamics (RcMcD), Hiroshima University, Higashi-Hiroshima, Japan) ,  Tochio Naoya (Faculty of Pharma-Sciences, Teikyo University, Tokyo, Japan) ,  Kawasaki Ryosuke (Department of Mathematical and Life Sciences, Graduate School of Science, Hiroshima University, Higashi-Hiroshima, Japan) ,  Matsuzaki Mizuki (Structural Biology Research Center, Graduate School of Science, Nagoya University, Japan) ,  Narita Akihiro (Structural Biology Research Center, Graduate School of Science, Nagoya University, Japan) ,  Kikumoto Mahito (Structural Biology Research Center, Graduate School of Science, Nagoya University, Japan) ,  Utsunomiya-Tate Naoko (Faculty of Pharma-Sciences, Teikyo University, Tokyo, Japan) ,  Tate Shin-ichi (Reseach Center for the Mathematics on Chromatin Live Dynamics (RcMcD), Hiroshima University, Higashi-Hiroshima, Japan) ,  Tate Shin-ichi (Department of Mathematical and Life Sciences, Graduate School of Science, Hiroshima University, Higashi-Hiroshima, Japan) ,  Ito Nobutoshi (Medical Research Institute, Tokyo Medical and Dental University, Japan)
Material： FEBS Letters  (for the Rapid Publication of Short Reports in Biochemistry, Biophysics)
Volume： 592  Issue： 18  Page： 3082-3091  Publication year： 2018 
JST Material Number： D0575A  ISSN： 0014-5793  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： In Alzheimer’s, the disease-re...

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Thesaurus term： *aggregation ,  *peptide ,  Amyloid ,  nerve fiber ,  phosphorylation ,  precursor (substance) ,  *isomer (molecule) ,  Alzheimer Disease ,  Peptidylprolyl Isomerase ,  Phosphopeptides ,  Catalytic Domain ,  *domain structure ,  *Pin1 ,  disease-associated proteins ,  hyperphosphorylation ,  Proteins ,  glycoprotein ,  animal protein

Author keywords (3)： Alzheimer’s disease ,  Pin1 ,  Tau

JST classification (2)： Biological function  (EB03040U) ,  Enzyme in general  (EB09010D)

Terms in the title (3)： Pin1 ,  凝集 ,  WWドメイン