Art

J-GLOBAL ID：201802259809597548   Reference number：18A0376865

Synthesis of 4′-Thionucleosides as Antitumor and Antiviral Agents

抗腫瘍薬および抗ウイルス薬としての4′-チオヌクレオシドの合成

Author (4)： Yoshimura Yuichi (Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University) ,  Saito Yukako (Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University) ,  Natori Yoshihiro (Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University) ,  Wakamatsu Hideaki (Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University)
Material： Chemical and Pharmaceutical Bulletin (Web)
Volume： 66  Issue： 2  Page： 139-146(J-STAGE)  Publication year： 2018 
JST Material Number： U1401A  ISSN： 1347-5223  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： Pummerer reaction ,...
Semi thesaurus term： Glycosylphosphatidylinositol-linked Proteins ,...

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Author keywords (12)： nucleoside ,  antitumor ,  antiviral ,  4′-thionucleoside ,  antiherpes virus ,  Pummerer reaction ,  nucleoside ,  antitumor ,  antiviral ,  4′-thionucleoside ,  antiherpes virus ,  Pummerer reaction

JST classification (1)： Drug therapy(=pharmacotherapy)for cardiovascular system diseases  (GJ05020M)

Substance index (14)： Aciclovir ,  Ganciclovir ,  Zidovudine ,  Sofosbuvir ,  Fumagillin ,  Lamivudine ,  1-[5α-(Hydroxymethyl)-2,5-dihydrothiophene-2α-yl]cytosine ,  1-[5α-(Hydroxymethyl)-5,6-dihydro-2H-thiopyran-2α-yl]cytosine ,  1-[5β,6α-Bis(hydroxymethyl)-5,6-dihydro-2H-thiopyran-2α-yl]cytosine ,  (2R,3R)-1-(tert-Butyldiphenylsiloxy)-3-(allylthiomethyl)-4-pentene-2-ol ,  4′-O-Thia-2′-methylene-2′-deoxycytidine ,  3β-(Benzyloxy)-4α-hydroxytetrahydrothiophene-2α-methanol ,  4α-(Benzyloxy)-5β-[(tert-butyldiphenylsilyloxy)methyl]tetrahydrothiophen-3β-ol ,  4'-O-Thiaguanosine

Reference (54)：

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• 4) Abratt R. P., Bezwoda W. R., Falkson G., Goedhals L., Hacking D., Rugg T. A., J. Clin. Oncol., 12, 1535-1540 (1994).
• 5) Elion G. B., Furman P. A., Fyfe J. A., de Miranda P., Beauchamp L., Schaeffer H. J., Proc. Natl. Acad. Sci. U.S.A., 74, 5716-5720 (1977).

Terms in the title (3)： 抗腫瘍薬 ,  抗ウイルス薬 ,  チオヌクレオシド