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J-GLOBAL ID：201802260948181267   Reference number：18A0569164

Toward industrial production of isoprenoids in Escherichia coli: Lessons learned from CRISPR-Cas9 based optimization of a chromosomally integrated mevalonate pathway

Escherichia coli中のイソプレノイドの工業生産に向けて:染色体に組み込まれたメバロン酸経路のCRISPR-Cas9に基づく最適化から学んだ教訓【Powered by NICT】

Author (24)： Alonso-Gutierrez Jorge (Joint BioEnergy Institute (JBEI), Emeryville, California) ,  Alonso-Gutierrez Jorge (Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, California) ,  Koma Daisuke (Joint BioEnergy Institute (JBEI), Emeryville, California) ,  Koma Daisuke (Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, California) ,  Koma Daisuke (Osaka Municipal Technical Research Institute, Osaka, Japan) ,  Hu Qijun (Joint BioEnergy Institute (JBEI), Emeryville, California) ,  Hu Qijun (Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, California) ,  Yang Yuchen (Joint BioEnergy Institute (JBEI), Emeryville, California) ,  Yang Yuchen (Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, California) ,  Chan Leanne J. G. (Joint BioEnergy Institute (JBEI), Emeryville, California) ,  Chan Leanne J. G. (Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, California) ,  Petzold Christopher J. (Joint BioEnergy Institute (JBEI), Emeryville, California) ,  Petzold Christopher J. (Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, California) ,  Adams Paul D. (Joint BioEnergy Institute (JBEI), Emeryville, California) ,  Adams Paul D. (Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, California) ,  Vickers Claudia E. (Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, St. Lucia, Queensland, Australia) ,  Nielsen Lars K. (Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, St. Lucia, Queensland, Australia) ,  Keasling Jay D. (Joint BioEnergy Institute (JBEI), Emeryville, California) ,  Keasling Jay D. (Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, California) ,  Keasling Jay D. (The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Horsholm, Denmark) ,  Keasling Jay D. (Department of Chemical and Biomolecular Engineering, University of California, Berkeley, California) ,  Keasling Jay D. (Department of Bioengineering, University of California, Berkeley, California) ,  Lee Taek S. (Joint BioEnergy Institute (JBEI), Emeryville, California) ,  Lee Taek S. (Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, California)
Material： Biotechnology and Bioengineering  (Biotechnol Bioeng)
Volume： 115  Issue： 4  Page： 1000-1013  Publication year： 2018 
JST Material Number： D0019A  ISSN： 0006-3592  CODEN： BIBIAU  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： Escherichia coli has been the ...

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Thesaurus term： *Escherichia coli ,  toxicity ,  genome ,  operon ,  cell death ,  *chromosome ,  promoter(genetics) ,  plasmid ,  *terpenoid ,  *optimization ,  alicyclic hydrocarbon ,  unsaturated hydrocarbon ,  polyene ,  aliphatic alcohol ,  aliphatic carboxylic acid ,  diol ,  hydroxy acid
Semi thesaurus term： 代謝工学 ,  *Cas9 ,  *CRISPR配列 , 【Automatic Indexing@JST】

Author keywords (6)： biofuel ,  chromosomal engineering ,  CRISPR-Cas9 ,  E. coli DH1 ,  mevalonate pathway ,  sucrose utilization

JST classification (1)： Gene manipulation  (EC02050B)

Substance index (2)： Bisabolene ,  Mevalonic Acid

Terms in the title (8)： Escherichia ,  イソプレノイド ,  工業 ,  染色体 ,  メバロン酸経路 ,  CRISPR-Cas9 ,  最適化 ,  教訓