Art

J-GLOBAL ID：201802264512185495   Reference number：18A0928303

Mechanism-Based Inhibitor of DNA Cytosine-5 Methyltransferase by a S_NAr Reaction with an Oligodeoxyribonucleotide Containing a 2-Amino-4-Halopyridine-C-Nucleoside

2-アミノ-4-ハロピリジン-C-ヌクレオシドを含むオリゴデオキシリボヌクレオチドとのS_NAR反応によるDNAシトシン-5メチルトランスフェラーゼの機構に基づく阻害剤【JST・京大機械翻訳】

Author (10)： Sato Kousuke (Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, 1757 Kanazawa, Tobetsu, Ishikari-gun, 061-0293, Japan) ,  Kunitomo Yuma (Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo, 060-0812, Japan) ,  Kasai Yukiko (Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo, 060-0812, Japan) ,  Utsumi Shohei (Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo, 060-0812, Japan) ,  Suetake Isao (Laboratory of Epigenetics, Institute for Protein Research, Osaka University, 3-2 Yamadaoka, Suita, Osaka, 565-0871, Japan) ,  Tajima Shoji (Laboratory of Epigenetics, Institute for Protein Research, Osaka University, 3-2 Yamadaoka, Suita, Osaka, 565-0871, Japan) ,  Ichikawa Satoshi (Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo, 060-0812, Japan) ,  Ichikawa Satoshi (Center for Research and Education on Drug Discovery, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, Japan) ,  Matsuda Akira (Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo, 060-0812, Japan) ,  Matsuda Akira (Center for Research and Education on Drug Discovery, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, Japan)
Material： ChemBioChem
Volume： 19  Issue： 8  Page： 865-872  Publication year： 2018 
JST Material Number： W1258A  ISSN： 1439-4227  CODEN： CBCHFX  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： In chromatin, 5-methylcytosine...

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Thesaurus term： *nucleoside ,  tumor cell ,  *methyltransferase ,  nucleic acid base ,  covalent bond ,  complex (substance) ,  *C-nucleoside ,  human ,  oligonucleotide ,  *DNA ,  molecular design ,  CpG sequence ,  DNA Methylation ,  *Oligodeoxyribonucleotides
Semi thesaurus term： 核酸医薬 , 【Automatic Indexing@JST】

Author keywords (5)： aromatic substitution ,  DNA methylation ,  epigenetics ,  nucleosides ,  oligonucleotides

JST classification (1)： Nucleic acids in general  (EB04010U)

Terms in the title (8)： ハロ ,  ピリジン ,  C-ヌクレオシド ,  オリゴデオキシリボヌクレオチド ,  DNA ,  シトシン ,  メチルトランスフェラーゼ ,  阻害剤