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J-GLOBAL ID：201802272195616166   Reference number：18A1785448

[6]-Gingerol Induces Amiloride-Sensitive Sodium Absorption in the Rat Colon via the Capsaicin Receptor TRPV1 in Colonic Mucosa

[6]-ギンゲロールは大腸粘膜のカプサイシン受容体TRPV1を介してラット大腸におけるアミロライド感受性ナトリウム吸収を誘導する

Author (2)： TSUCHIYA Yo (Department of Health and Nutrition, Faculty of Home Economics, Tohoku Women’s College) ,  KAWAMATA Koichi (Department of Domestic Science, Faculty of Domestic Science, Tohoku Seikatsu Bunka University)
Material： Journal of Nutritional Science and Vitaminology (Web)
Volume： 64  Issue： 4  Page： 287-291(J-STAGE)  Publication year： 2018 
JST Material Number： U1313A  ISSN： 1881-7742  Document type： Article
Article type： 短報  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *spice ,...
Semi thesaurus term： functional ingredient ,...

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Author keywords (4)： [6]-gingerol ,  colon epithelium ,  electrogenic sodium absorptionen ,  TRPV1

JST classification (2)： Seasonings,spices(=condiments)  (FJ10010W) ,  Intestines  (EJ06040N)

Substance index (3)： 6-Gingerol ,  Capsazepine ,  Amiloride

Reference (27)：

• 1) Kim SO, Kim MR. 2013. [6]-Gingerol prevents disassembly of cell junctions and activities of MMPs in invasive human pancreas cancer cells through ERK/NF-κB/snail signal transduction pathway. Evid Based Complement Alternat Med 2013: 761852.
• 2) Ahui ML, Champy P, Ramadan A, Pham Van L, Araujo L, Brou André K, Diem S, Damotte D, Kati-Coulibaly S, Offoumou MA, Dy M, Thieblemont N, Herbelin A. 2008. Ginger prevents Th2-mediated immune responses in a mouse model of airway inflammation. Int Immunopharmacol 8: 1626-1632.
• 3) Kawai T, Kinoshita K, Koyama K, Takahashi K. 1994. Anti-emetic principles of Magnolia obovata bark and Zingiber officinale rhizome. Planta Med 60: 17-20.
• 4) Yang Y, Kinoshita K, Koyama K, Takahashi K, Kondo S, Watanabe K. 2002. Structure-antiemetic-activity of some diarylheptanoids and their analogues. Phytomedicine 9: 146-152.
• 5) Abdel-Aziz H, Windeck T, Ploch M, Verspohl EJ. 2006. Mode of action of gingerols and shogaols on 5-HT₃ receptors: binding studies, cation uptake by the receptor channel and contraction of isolated guinea-pig ileum. Eur J Pharmacol 530: 136-143.

Terms in the title (10)： ギンゲロール ,  大腸粘膜 ,  カプサイシン受容体 ,  TRPV1 ,  ラット ,  大腸 ,  アミロライド ,  感受性 ,  ナトリウム ,  誘導