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J-GLOBAL ID：201802272784851135   Reference number：18A0392779

A new paradigm for drug-induced torsadogenic risk assessment using human iPS cell-derived cardiomyocytes

ヒトiPS細胞由来心筋細胞を用いた薬物誘発torsadogenicリスク評価のための新しいパラダイム【Powered by NICT】

Author (46)： Ando Hiroyuki ( http://jicsa.org/.) ,  Ando Hiroyuki (Japanese Safety Pharmacology Society (JSPS), 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan http://www.j-sps.org/.) ,  Ando Hiroyuki (Safety Research Laboratories, Ono Pharmaceutical Co., Ltd., 50-10 Yamagishi, Mikuni-cho, Sakai-shi, Fukui 913-8538, Japan) ,  Yoshinaga Takashi ( http://jicsa.org/.) ,  Yoshinaga Takashi (Japanese Safety Pharmacology Society (JSPS), 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan http://www.j-sps.org/.) ,  Yoshinaga Takashi (Biopharmaceutical Assessments Core Function Unit, Medicine Development Center, Eisai Co., Ltd., 5-1-3 Tokodai, Tsukuba, Ibaraki 300-2635, Japan) ,  Yamamoto Wataru ( http://jicsa.org/.) ,  Yamamoto Wataru (Pharmaceutical Development Research Laboratories, Toxicology Research Department, Teijin Pharma Limited, 4-3-2 Asahigaoka, Hino-shi, Tokyo 191-8512, Japan) ,  Asakura Keiichi ( http://jicsa.org/.) ,  Asakura Keiichi (Japanese Safety Pharmacology Society (JSPS), 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan http://www.j-sps.org/.) ,  Asakura Keiichi (Discovery Research Labs., Nippon Shinyaku Co., Ltd., 14 Nishinosho-monguchi-cho, Kisshoin, Minami-ku, Kyoto 601-8550, Japan) ,  Uda Takaaki ( http://jicsa.org/.) ,  Uda Takaaki (Safety Research Laboratories, Ono Pharmaceutical Co., Ltd., 50-10 Yamagishi, Mikuni-cho, Sakai-shi, Fukui 913-8538, Japan) ,  Taniguchi Tomohiko ( http://jicsa.org/.) ,  Taniguchi Tomohiko (Biopharmaceutical Assessments Core Function Unit, Medicine Development Center, Eisai Co., Ltd., 5-1-3 Tokodai, Tsukuba, Ibaraki 300-2635, Japan) ,  Ojima Atsuko ( http://jicsa.org/.) ,  Ojima Atsuko (Biopharmaceutical Assessments Core Function Unit, Medicine Development Center, Eisai Co., Ltd., 5-1-3 Tokodai, Tsukuba, Ibaraki 300-2635, Japan) ,  Shinkyo Raku (Biopharmaceutical Assessments Core Function Unit, Medicine Development Center, Eisai Co., Ltd., 5-1-3 Tokodai, Tsukuba, Ibaraki 300-2635, Japan) ,  Kikuchi Kiyomi (Biopharmaceutical Assessments Core Function Unit, Medicine Development Center, Eisai Co., Ltd., 5-1-3 Tokodai, Tsukuba, Ibaraki 300-2635, Japan) ,  Osada Tomoharu ( http://jicsa.org/.) ,  Osada Tomoharu (Japanese Safety Pharmacology Society (JSPS), 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan http://www.j-sps.org/.) ,  Osada Tomoharu (Drug Development Service Segment, LSI Medience Corporation, 13-4 Uchikanda 1-chome, Chiyoda-ku, Tokyo 101-8517, Japan) ,  Hayashi Seiji ( http://jicsa.org/.) ,  Hayashi Seiji (Japanese Safety Pharmacology Society (JSPS), 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan http://www.j-sps.org/.) ,  Hayashi Seiji (Discovery Research Labs., Nippon Shinyaku Co., Ltd., 14 Nishinosho-monguchi-cho, Kisshoin, Minami-ku, Kyoto 601-8550, Japan) ,  Kasai Chieko ( http://jicsa.org/.) ,  Kasai Chieko (Japanese Safety Pharmacology Society (JSPS), 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan http://www.j-sps.org/.) ,  Kasai Chieko (Drug Safety Research Laboratories, Astellas Pharma Inc., 21, Miyukigaoka, Tsukuba-shi, Ibaraki 305-8585, Japan) ,  Miyamoto Norimasa ( http://jicsa.org/.) ,  Miyamoto Norimasa (Biopharmaceutical Assessments Core Function Unit, Medicine Development Center, Eisai Co., Ltd., 5-1-3 Tokodai, Tsukuba, Ibaraki 300-2635, Japan) ,  Tashibu Hiroyuki ( http://jicsa.org/.) ,  Tashibu Hiroyuki (Japanese Safety Pharmacology Society (JSPS), 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan http://www.j-sps.org/.) ,  Tashibu Hiroyuki (Research Administration Department, Ina Research Inc., 2148-188 Nishiminowa, Ina-shi, Nagano 399-4501, Japan) ,  Yamazaki Daiju ( http://jicsa.org/.) ,  Yamazaki Daiju (Division of Pharmacology, National Institute of Health Sciences (NIHS), 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan) ,  Sugiyama Atsushi ( http://jicsa.org/.) ,  Sugiyama Atsushi (Japanese Safety Pharmacology Society (JSPS), 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan http://www.j-sps.org/.) ,  Sugiyama Atsushi (Department of Pharmacology, Faculty of Medicine, Toho University, 5-21-16 Omori-nishi, Ota-ku, Tokyo 143-8540, Japan) ,  Kanda Yasunari ( http://jicsa.org/.) ,  Kanda Yasunari (Division of Pharmacology, National Institute of Health Sciences (NIHS), 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan) ,  Sawada Kohei ( http://jicsa.org/.) ,  Sawada Kohei (Japanese Safety Pharmacology Society (JSPS), 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan http://www.j-sps.org/.) ,  Sawada Kohei (Biopharmaceutical Assessments Core Function Unit, Medicine Development Center, Eisai Co., Ltd., 5-1-3 Tokodai, Tsukuba, Ibaraki 300-2635, Japan) ,  Sekino Yuko ( http://jicsa.org/.) ,  Sekino Yuko (Japanese Safety Pharmacology Society (JSPS), 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan http://www.j-sps.org/.) ,  Sekino Yuko (Division of Pharmacology, National Institute of Health Sciences (NIHS), 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan)
Material： Journal of Pharmacological and Toxicological Methods  (J Pharmacol Toxicol Method)
Volume： 84  Page： 111-127  Publication year： 2017 
JST Material Number： A0132B  ISSN： 1056-8719  CODEN： JPTMEZ  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Human induced pluripotent stem...

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Thesaurus term： depolarization(physiology) ,  *human(primates) ,  *cardiac myocyte ,  *risk assessment ,  two dimension ,  plasma concentration ,  therapy ,  *induced pluripotent stem cell
Semi thesaurus term： リスクスコア ,  スコア ,  トルサード型心室頻拍 ,  平衡透析法 ,  危険予測 ,  催不整脈作用 ,  *ヒトiPS細胞 , 【Automatic Indexing@JST】

Author keywords (10)： Concordance ,  Early afterdepolarization ,  Field potential duration ,  Free concentration ,  Human induced pluripotent stem cell-derived cardiomyocytes ,  Multi-electrode array ,  Proarrhythmia ,  Risk categorisation ,  Torsade de pointes ,  Torsadogenic risk

JST classification (1)： Research and development  (GU01040N)

Terms in the title (6)： ヒトiPS細胞 ,  心筋細胞 ,  薬物 ,  誘発 ,  リスク評価 ,  パラダイム