Art

J-GLOBAL ID：201802274612710289   Reference number：18A2167160

Synthesis of Trifluoromethyl-α,β-unsaturated Lactones and Pyrazolinones and Discovery of Influenza Virus Polymerase Inhibitors

トリフルオロメチル-α,β-不飽和ラクトンおよびピラゾリノンの合成およびインフルエンザウイルスポリメラーゼ阻害剤の発見【JST・京大機械翻訳】

Author (7)： Mizuta Satoshi (Graduate School of Biomedical Sciences, Nagasaki University, 1-14 Bunkyo-machi, Nagasaki, 852-8521, Japan) ,  Makau Juliann Nzembi (Department of Molecular Microbiology and Immunology, Graduate School of Biomedical Sciences, Nagasaki University, 1-12-4 Sakamoto, Nagasaki, 852-8523, Japan) ,  Kitagawa Ayako (Graduate School of Biomedical Sciences, Nagasaki University, 1-14 Bunkyo-machi, Nagasaki, 852-8521, Japan) ,  Kitamura Kanami (Graduate School of Biomedical Sciences, Nagasaki University, 1-14 Bunkyo-machi, Nagasaki, 852-8521, Japan) ,  Otaki Hiroki (Graduate School of Biomedical Sciences, Nagasaki University, 1-14 Bunkyo-machi, Nagasaki, 852-8521, Japan) ,  Nishi Kodai (Department of Radioisotope Medicine, Atomic Bomb Disease Institute, Nagasaki University, 1-12-4 Sakamoto, Nagasaki, 852-8523, Japan) ,  Watanabe Ken (Department of Molecular Microbiology and Immunology, Graduate School of Biomedical Sciences, Nagasaki University, 1-12-4 Sakamoto, Nagasaki, 852-8523, Japan)
Material： ChemMedChem
Volume： 13  Issue： 22  Page： 2390-2399  Publication year： 2018 
JST Material Number： W1573A  ISSN： 1860-7179  CODEN： CHEMGX  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： To explore the potential biolo...

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Thesaurus term： State of California ,  *influenza virus ,  cytotoxicity ,  biological activity ,  Structure-Activity Relationship ,  *influenza ,  antibacterial action ,  optimization ,  clinical isolate ,  inhibitory activity ,  *polymerase inhibitor ,  *microorganism ,  modification
Semi thesaurus term： *阻害剤 , 【Automatic Indexing@JST】

Author keywords (5)： cross-coupling ,  influenza virus ,  inhibitors ,  RNA-dependent RNA polymerase ,  trifluoromethyl group

JST classification (2)： Addition reaction,elimination reaction  (CF02030M) ,  Aliphatic halogen compounds  (CF03050P)

Terms in the title (5)： 不飽和 ,  ラクトン ,  インフルエンザウイルス ,  ポリメラーゼ阻害剤 ,  発見