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J-GLOBAL ID：201802277562953226   Reference number：18A0337009

Synthesis of PET probe O ⁶-[(3-[¹¹C]methyl)benzyl]guanine by Pd⁰-mediated rapid C-[¹¹C]methylation toward imaging DNA repair protein O ⁶-methylguanine-DNA methyltransferase in glioblastoma

神経膠芽腫における画像DNA修復蛋白質O~6メチルグアニンDNAメチルトランスフェラーゼに対するPd~0仲介迅速C-[~11C]メチル化によるPETプローブO~-6-[(3-[~11C]メチル)ベンジル]グアニンの合成【Powered by NICT】

Author (12)： Koyama Hiroko (Division of Regeneration and Advanced Medical Science, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu 501-1194, Japan) ,  Ikenuma Hiroshi (Department of Clinical and Experimental Neuroimaging, Center for Development of Advanced Medicine for Dementia, National Center for Geriatrics and Gerontology, 7-430 Morioka-cho, Obu-shi, Aichi 474-8511, Japan) ,  Toda Hiroshi (Department of Neurosurgery, Nagoya University School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan) ,  Kondo Goro (Department of Neurosurgery, Nagoya University School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan) ,  Hirano Masaki (Department of Neurosurgery, Nagoya University School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan) ,  Kato Masaya (Division of Regeneration and Advanced Medical Science, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu 501-1194, Japan) ,  Abe Junichiro (Department of Clinical and Experimental Neuroimaging, Center for Development of Advanced Medicine for Dementia, National Center for Geriatrics and Gerontology, 7-430 Morioka-cho, Obu-shi, Aichi 474-8511, Japan) ,  Yamada Takashi (Department of Food and Nutritional Science, College of Bioscience and Biotechnology, Chubu University, Matsumoto-cho, Kasugai, Aichi 487-8501, Japan) ,  Wakabayashi Toshihiko (Department of Neurosurgery, Nagoya University School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan) ,  Ito Kengo (Department of Clinical and Experimental Neuroimaging, Center for Development of Advanced Medicine for Dementia, National Center for Geriatrics and Gerontology, 7-430 Morioka-cho, Obu-shi, Aichi 474-8511, Japan) ,  Natsume Atsushi (Department of Neurosurgery, Nagoya University School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan) ,  Suzuki Masaaki (Department of Clinical and Experimental Neuroimaging, Center for Development of Advanced Medicine for Dementia, National Center for Geriatrics and Gerontology, 7-430 Morioka-cho, Obu-shi, Aichi 474-8511, Japan)
Material： Bioorganic & Medicinal Chemistry Letters  (Bioorg Med Chem Lett)
Volume： 27  Issue： 9  Page： 1892-1896  Publication year： 2017 
JST Material Number： W0248A  ISSN： 0960-894X  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： O ⁶-Benzylguanine (...

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Thesaurus term： *probe ,  *DNA methyltransferase ,  *protein ,  *methylation ,  precursor(substance) ,  drug therapy ,  drug resistance ,  substrate(biochemistry) ,  deprotection ,  *DNA repair ,  *image ,  PET(tomography) ,  *glioblastoma ,  amine
Semi thesaurus term： 臨床診断 , 【Automatic Indexing@JST】

Author keywords (5)： ¹¹C labeling ,  O ⁶-Benzylguanine ,  Positron emission tomography probe ,  Rapid C-[¹¹C]methylation ,  Brain cancer imaging

JST classification (3)： Synthesis of drugs  (GV01030F) ,  Basic research of antitumor(=antineoplastic)drugs  (GW16010A) ,  Structure-activity relationship of drugs  (GV01050B)

Terms in the title (10)： 神経膠芽腫 ,  DNA修復 ,  蛋白質 ,  メチルグアニン ,  DNAメチルトランスフェラーゼ ,  仲介 ,  メチル化 ,  PETプローブ ,  ベンジル ,  グアニン