Art

J-GLOBAL ID：201802277635664801   Reference number：18A2058038

Evaluation of miR-122 to Predict High Dose Acetaminophen-Induced Liver Injury in Mice: The Combination Uses of 5-Fluorouracil

マウスにおけるmiR-122の高用量アセトアミノフェン誘発肝障害予測能の評価:5-フルオロウラシルの併用

Author (11)： Munakata Chie (Department of Pharmaceutical Informatics, Graduate School of Biomedical Sciences, Nagasaki University) ,  Munakata Chie (Department of Hospital Pharmacy, Nagasaki University Hospital) ,  Fuchigami Yuki (Department of Pharmaceutical Informatics, Graduate School of Biomedical Sciences, Nagasaki University) ,  Hiroishi Shu (Department of Pharmaceutical Informatics, Graduate School of Biomedical Sciences, Nagasaki University) ,  Haraguchi Ayana (Department of Pharmaceutical Informatics, Graduate School of Biomedical Sciences, Nagasaki University) ,  Hagimori Masayori (Department of Pharmaceutical Informatics, Graduate School of Biomedical Sciences, Nagasaki University) ,  Enomoto Hatsune (Scientific Research and Business Development Department, Towa Pharmaceutical Co., Ltd.) ,  Tachiki Hidehisa (Scientific Research and Business Development Department, Towa Pharmaceutical Co., Ltd.) ,  Kodama Yukinobu (Department of Hospital Pharmacy, Nagasaki University Hospital) ,  Sasaki Hitoshi (Department of Hospital Pharmacy, Nagasaki University Hospital) ,  Kawakami Shigeru (Department of Pharmaceutical Informatics, Graduate School of Biomedical Sciences, Nagasaki University)
Material： Biological and Pharmaceutical Bulletin (Web)
Volume： 41  Issue： 11  Page： 1732-1735(J-STAGE)  Publication year： 2018 
JST Material Number： U1402A  ISSN： 1347-5215  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： mouse(animal) ,...
Semi thesaurus term： *miR-122 ,...

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Author keywords (8)： acetaminophen ,  micro RNA-122 ,  biomarker ,  liver injury ,  acetaminophen ,  micro RNA-122 ,  biomarker ,  liver injury

JST classification (4)： Basic research of antipyretic analgesics  (GW03040H) ,  Poisoning in general  (GD06010Q) ,  Interactions of drugs  (GV01070X) ,  Basic research of antitumor(=antineoplastic)drugs  (GW16010A)

Substance index (2)： Acetaminophen ,  Fluorouracil

Reference (15)：

• 1) McGill MR, Jaeschke H. Metabolism and disposition of acetaminophen: recent advances in relation to hepatotoxicity and diagnosis. Pharm. Res., 30, 2174-2187 (2013).
• 2) Harman AW, Kyle ME, Serroni A, Farber JL. The killing of cultured hepatocytes by N-acetyl-p-benzoquinone imine (NAPQI) as a model of the cytotoxicity of acetaminophen. Biochem. Pharmacol., 41, 1111-1117 (1991).
• 3) Larson AM, Polson J, Fontana RJ, Davern TJ, Lalani E, Hynan LS, Reisch JS, Schiødt FV, Ostapowicz G, Shakil AO, Lee WM. Acetaminophen-induced acute liver failure: Results of a United States multicenter, prospective study. Hepatology, 42, 1364-1372 (2005).
• 4) Sattar N, Scherbakova O, Ford I, O’Reilly DS, Stanley A, Forrest E, Macfarlane PW, Packard CJ, Cobbe SM, Shepherd J. Elevated alanine aminotransferase predicts new-onset type 2 diabetes independently of classical risk factors, metabolic syndrome, and C-reactive protein in the west of Scotland coronary prevention study. Diabetes, 53, 2855-2860 (2004).
• 5) Ladue JS, Wroblewski F. The significance of the serum glutamic oxalacetic transaminase activity following acute myocardial infarction. Circulation, 11, 871-877 (1955).

Terms in the title (10)： マウス ,  miR-122 ,  高用量 ,  アセトアミノフェン ,  誘発 ,  肝障害 ,  予測 ,  評価 ,  5-フルオロウラシル ,  併用